| Description |
1 online resource |
| Series |
CRC revivals |
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CRC revivals.
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| Contents |
Cover; Title Page; Copyright Page; Preface; Author; Table of Contents; PART I -GLUCURONIDATION, GLUCURONIDES, AND STUDIES ON UDPGLUCURONYLTRANSFERASE IN VITRO; Chapter 1: Introduction -- The Biological Function of Glucuronidation; I. What Glucuronidation Is; II." Detoxication" Reactions; III. Distinctive Aspects of the Phase 2 Reactions of Detoxication; IV. The Concept of Detoxication; V. Xenobiotics and Evolution; VI. Competition by Xenobiotics in Routine Glucuronidation; A. General; B. Competition for Materials; C. Competition for Enzyme Sites; VII. Why Glucuronidation is a Major Pathway |
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VIII. Analogous GlycosidationIX. Metabolic Role of Glucuronidation; A. General; B. Metabolic Role of Steroid Glucuronides; C. Metabolic Role of Other Glucuronides; 1. Absorption; 2. Binding of Toxic Glucuronides; 3. Role of the Hydrolysis of Glucuronides in Their Metabolism; X. Additional Notes; Chapter 2: Structure and Properties of Glucuronides; I. Chemical Structures Glucuronidated; II. Chemical Properties of Glucuronides; A. O-Glucuronides; 1. Aryl-O- (Phenolic) Glucuronides; 2. Aryl- or Alkyl-O- (Enolic) Glucuronides; 3. Alkyl-O- Glucuronides |
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4. Acyl-O- Glucuronides ("Ester Glucuronides ")B. S-Glucuronides; C. N-Glucuronides; D. C-Glucuronides; III. Physicochemical Properties of Glucuronides; Chapter 3: Mechanism of Glucuronidation; I. Historical Background; A. Work up to 1950; B. Isolation of UDPGlucuronic Acid and Identification of UDPGlucu- ronyltransferase; II. Glucuronidation Involving Sugar Nucleotides; A. Specificity of Sugar Nucleotides as Glucuronyl D onors; B. Lipid Acceptors of Glucuronic Acid; C. Transglucuronylation with UDPGlucuronyltransferase; III. Glucuronidation Not Involving Sugar Nucleotides |
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A. Transglucuronylation with Other EnzymesB. Nonenzymic Glucuronidation; IV. Additional Notes; Chapter 4: Location of UDPGlucuronyltransferase in the Cell; I. Introduction; II. Location of UDPGlucuronyltransferase Among Cellular Fractions; A. General; B. Distribution Among Rough and Smooth Endoplasmic Reticulum of the Liver Cell; C. Occurrence in " Microsomal Fractions" of Extrahepatic Tissues; D. Occurrence in Nuclear Envelope; E. Occurrence in Other Cell Fractions; 1. Mitochondria; 2. Cytoplasm; 3. Golgi Apparatus and Plasma Membranes; F. Occurrence in Nonparenchymal Liver Cells |
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III. Location of UDPGlucuronyltransferase Within the MembraneIV. Additional Notes; Chapter 5: Factors Affecting UDPGlucuronyltransferase Activity In Vitro; I. Latency and Activation: Introduction; A. Latency; 1. Latency -- an Artifact or Not?; 2. Evidence from Comparison of Transferase Activity with Over- all Glucuronidation; 3. Evidence from Kinetic Studies; 4. Evidence from Nuclei; II. Activation and Inhibition Procedures; A. Mechanical Disruption; B. Temperature; C. Storage; D. Centrifugation; E. Surfactants; F. Chaotropic Agents; G. Organic Solvents |
| Summary |
Published in 1980: In a previous publication on glucuronic acid both free and conjugated, the author expressed the hope that glucuronic acid studies over the following few years might expand vigorously. The have expanded, and none more vigorously that the study of biosynthesis of simple glucuronides |
| Notes |
Originally published in 1980 |
| Bibliography |
Includes bibliographical references and index |
| Notes |
G.J. Dutton is Professor of Pharmacological Biochemistry in the University of Dundee, Scotland |
| Subject |
Drugs -- Metabolism.
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Glucuronic acid -- Synthesis.
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MEDICAL -- Pharmacology.
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MEDICAL -- Biochemistry.
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Drugs -- Metabolism
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Glucuronic acid -- Synthesis
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| Form |
Electronic book
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| ISBN |
0429264178 |
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9780429264177 |
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9780429554735 |
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0429554737 |
|
9780429563676 |
|
0429563671 |
|
9780429559204 |
|
0429559208 |
|
