Description |
1 online resource (85 pages) : illustrations (some color) |
Series |
Integrated systems physiology, from molecule to function to disease ; bk. #22 |
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Colloquium series on integrated systems physiology ; #22.
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Contents |
Part I. Efferent renal sympathetic nerves -- 1. Introduction |
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2. Neuroanatomy -- 2.1 Neural pathways -- 2.2 Intrarenal distribution of efferent renal sympathetic nerves -- 2.3 Characteristics of the efferent renal sympathetic nerve signals -- 2.4 Neurotransmitters -- 2.5 Adrenoceptors -- 2.6 Angiotensin II, nitric oxide, and reactive oxygen species |
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3. Neural control of renal hemodynamics -- 3.1 Measurements of renal blood flow -- 3.2 Renal denervation -- 3.3 Increases in renal sympathetic nerve activity -- 3.4 Adrenoceptors |
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4. Neural control of renal tubular function -- 4.1 Renal denervation -- 4.2 Increases in renal sympathetic nerve activity -- 4.2.1 Direct activation of the renal nerves -- 4.2.2 Reflex-mediated increases and decreases in the activation of the renal nerves -- 4.3 Adrenoceptors |
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5. Neural control of renin secretion rate -- 5.1 Increases in efferent renal sympathetic nerve activity -- 5.2 Interaction between neural and non-neural mechanisms for renin secretion -- 5.3 Adrenoceptor |
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Part II. Afferent renal sensory nerves -- 6. Introduction |
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7. Neuroanatomy -- 7.1 Kidney -- 7.2 Projection to the central nervous system |
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8. Renorenal reflexes -- 8.1 Activation of afferent renal sensory nerves by physiological stimuli -- 8.2 Selective afferent renal denervation-dorsal rhizotomy -- 8.3 Interaction between efferent and afferent renal nerve activity |
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9. Mechanisms involved in the activation of afferent renal sensory nerves -- 9.1 Substance P -- 9.2 Mechanisms contributing to the release of substance P from renal pelvic sensory nerves -- 9.2.1 PGE2 -- 9.2.2 Angiotensin II -- 9.2.3 Endothelin -- Part III. Pathophysiological states |
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10. Efferent renal sympathetic nerves -- 10.1 Hypertension -- 10.2 Heart failure -- 10.3 Cirrhosis and nephrotic syndrome |
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11. Afferent renal sensory nerves |
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12. Conclusions -- References -- Author biography |
Summary |
The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of [alpha]1-adrenoceptors and increase renin secretion rate by activation of [beta]1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Activation of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension |
Analysis |
efferent renal sympathetic nerves |
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afferent renal nerves |
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norepinephrine |
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substance P |
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renal innervation |
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renal mechanosensory nerves |
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adrenoceptors |
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prostaglandins |
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sodium |
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renin secretion |
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hypertension |
Bibliography |
Includes bibliographical references (pages 65-84) |
Subject |
Kidneys -- Physiology
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Kidneys -- Innervation.
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Kidneys -- Diseases.
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Neurophysiology.
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Neural transmission.
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Norepinephrine.
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Kidney -- innervation
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Synaptic Transmission
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Norepinephrine
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Receptors, Adrenergic -- physiology
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Sympathetic Nervous System -- drug effects
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Kidney Diseases
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Neurophysiology
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MEDICAL -- Surgery -- General.
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Norepinephrine
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Neural transmission
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Kidneys -- Diseases
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Kidneys -- Innervation
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Kidneys -- Physiology
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Neurophysiology
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Form |
Electronic book
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ISBN |
9781615042326 |
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1615042326 |
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