| Description |
1 online resource (xiv, 220 pages) : color illustrations |
| Series |
Springer theses |
|
Springer theses.
|
| Contents |
Introduction -- Results and Discussion -- Conclusion -- Experimental Section -- References -- Appendix I -- Appendix II |
| Summary |
In his thesis, Xiao-yu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiao-yu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and contains a five-membered peroxide ring, with oxygen atoms linked to tertiary C4 and C6 centers. The methodology used for synthesizing highly substituted cyclic peroxides is novel and useful, and not only extends the field of Pd-catalyzed reactions, but also provides a convenient synthetic approach for the preparation of the 1,2-dioxolanes series. Plakortide E and plakortone B are bioactive, which means that the synthetic studies on them and their analogs are pivotal in drug discovery |
| Analysis |
Chemistry |
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Biochemistry |
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Catalysis |
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Organic Chemistry |
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Medicinal Chemistry |
| Notes |
"Doctoral thesis accepted by The Chinese University of Hong Kong." |
|
Ph. D. Chinese University of Hong Kong |
| Bibliography |
Includes bibliographical references |
| Subject |
Peroxides -- Synthesis
|
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Stereoisomers -- Synthesis
|
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SCIENCE -- Chemistry -- Organic.
|
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Science des matériaux.
|
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Chimie.
|
| Genre/Form |
doctoral dissertations.
|
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theses.
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dissertations.
|
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masters theses.
|
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Academic theses
|
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Academic theses.
|
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Thèses et écrits académiques.
|
| Form |
Electronic book
|
| ISBN |
9783642271953 |
|
3642271952 |
|
3642271944 |
|
9783642271946 |
|
