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Title Sphingosine-1-phosphate signaling in immunology and infectious diseases / Michael B.A. Oldstone, Hugh Rosen, editors
Published Cham ; New York : Springer, [2014]


Description 1 online resource (vii, 184 pages) : illustrations
Series Current topics in microbiology and immunology, 0070-217X ; volume 378
Current topics in microbiology and immunology ; 378. 0070-217X
Contents The organization of the sphingosine-1-phosphate signaling system / Hugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera and Edward Roberts -- Structural biology of the S1P₁ receptor / Michael A. Hanson and Robert Peach -- Chemical and genetic tools to explore S1P biology / Stuart M. Cahalan -- S1P control of endothelial integrity / Yuquan Xiong and Timothy Hla -- Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen / Tal I. Arnon and Jason G. Cyster -- Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule / Michael B.A. Oldstone and Hugh Rosen -- Sphingosine-1-phosphate and central nervous system / Roland Martin and Mireia Sospedra -- RORs in autoimmune disease / Mi Ra Chang, Hugh Rosen and Patrick R. Griffin
Summary This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses
Analysis biomedische wetenschappen
infectious diseases
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes English
PDF title page (viewed April 22, 2014)
In Springer eBooks
Subject Immunopharmacology.
Sphingosine -- Immunology
Phosphates -- Immunology
Emerging infectious diseases.
Allergy and Immunology
Communicable Diseases, Emerging
MEDICAL -- Pharmacology.
Form Electronic book
Author Oldstone, Michael B. A., editor.
Rosen, Hugh (Professor of chemical physiology), editor.
ISBN 9783319058795