| Description |
1 online resource (xxvi, 1151 pages) |
| Contents |
Cover; Title page; Copyright page; Contents; Contributors; Foreword; References; Preface; Part I -- Introduction; Chapter 1 -- What Can We Model?; Animal models of seizures; Animal models of epilepsy; A way forward; References; Chapter 2 -- Comparative Biology and Species Effects on Expression of Epilepsy; Introduction; How does epilepsy vary across species?; Conservative brain evolution; Vertebrate Phylogeny; Similarities Across Vertebrate Brains; Brain size; Brain Size Affects Circuitry; Mechanisms of brain evolution; Invasion; Loss of Connections; Parcellation; Ontogenetic Buffers |
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Axon DisplacementConcerted and Mosaic Brain Evolution; Tool for Comparing Developmental Stages Across Species; Evolution of the neocortex and hippocampus; Eversion of the Teleost Telencephalon; Amphibian Dorsal Pallium; Reptilian Dorsal Pallium; Dorsal Ventricular Ridge of Reptiles and Birds; Mammalian Neocortex; Pyramidal Cell Evolution; Neocortical Areas; Thalamus; Hippocampal Evolution; Epilepsy-Relevant Species-Specific Hippocampal Characteristics; Conclusions; Acknowledgments; References; Chapter 3 -- Strain Effects on Expression of Seizures and Epilepsy; Introduction |
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Mouse strain effects on expression of seizures and epilepsyMouse Models of Acute Seizures and Seizure Susceptibility; Physically-Induced Seizures; Chemically-Induced Seizures; Antiseizure Drugs; The 6-Hz Psychomotor Seizure Model of Partial Epilepsy in Mice; Mouse Strain Differences in Occurrence of Spike-Wave Discharges; The Pilocarpine Model of Temporal Lobe Epilepsy in Mice; The Kainate Model of Temporal Lobe Epilepsy in Mice; The Intrahippocampal Kainate Model of Temporal Lobe Epilepsy in Mice; The Electrical Kindling Model of Temporal Lobe Epilepsy in Mice |
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The Flurothyl Kindling Mouse Model of Primary Generalized EpilepsiesThe Theiler's Virus Mouse Model of Encephalitis-Induced Temporal Lobe Epilepsy; Rat strain effects on expression of seizures and epilepsy; The Pilocarpine Model of Temporal Lobe Epilepsy in Rats; The Electrical Kindling Model of Temporal Lobe Epilepsy in Rats; Sustained Stimulation of the Basolateral Amygdala in Rats as a Model of Temporal Lobe Epilepsy; Rat Strain Differences in Occurrence of Spike-Wave Discharges or Other EEG Alterations |
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Dissection of genes that may underlie differences in expression of seizures or epilepsySignal-Recognition-Particle Assembly 9 (Srp9); Potassium Voltage-Gated Channel Subfamily J Member 10 (Kcnj10); Multiple PDZ Domain Crumbs Cell Polarity Complex Component (Mpdz); Cholinergic Receptor Genes; Conclusions; Acknowledgments; References; Further Reading; Chapter 4 -- Good Welfare Practice in Modeling Seizures and Epilepsy; General description; Background; Ethics and animal research; Legal Framework; NC3Rs report on welfare in rodent epilepsy models; Intrinsic features of epilepsy models; Seizures |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Vendor-supplied metadata |
| Subject |
Epilepsy.
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Spasms.
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Epilepsy -- Animal models
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Convulsions.
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Epilepsy
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Seizures
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Models, Animal
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Spasm
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Convulsions
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Epilepsy
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Epilepsy -- Animal models
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Spasms
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| Form |
Electronic book
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| Author |
Pitkänen, Asla, editor.
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Buckmaster, Paul S., editor.
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Galanopoulou, Aristea S., 1965- editor.
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Moshé, Solomon L., editor.
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| LC no. |
2016960799 |
| ISBN |
9780128040676 |
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012804067X |
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