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Title Small molecule microarrays : methods and protocols / edited by Mahesh Uttamchandani, Shao Q. Yao
Edition Second edition
Published New York : Humana Press : Springer, ©2017


Description 1 online resource (xi, 260 pages) : color illustrations
Series Methods in molecular biology ; v. 1518
Methods in molecular biology (Clifton, N.J.) ; v. 1518. 1064-3745
Contents Expanding world of small molecule microarrays / Mahesh Uttamchandani and Shao Q. Yao -- Novel substrates for microarrays / Dameng Guo, Han Wu, Liang Wu, and Bo Zheng -- Fabrication of bio-function-preserved saccharide microarray chips with cyanuric chloride as a rotatable linker / Yi Chen, Chanjuan Liu, and Xiao Wang -- Fabrication of carbohydrate microarrays by boronate formation / Avijit K. Adak, Ting-Wei Lin, Ben-Yuan Li, and Chun-Cheng Lin -- Clickable polymeric coating for glycan microarrays / Caterina Zilio, Laura Sola, Marina Cretich, Anna Bernardi, and Marcella Chiari -- Versatile microarray immobilization strategy based on a biorthogonal reaction between tetrazine and trans-cyclooctene / Ping Wang, Liqian Gao, Haipeng Lei, Su Seong Lee, Shao Q. Yao, and Hongyan Sun -- Label-free sensing on microarrays / Yung-Shin Sun -- Optical microscopy for detecting binding on small molecule microarrays / Si Ying Png, Sherlyn Xiang Bing Seah, and Zhiqiang Gao -- Array-on-array strategy for activity-based enzyme profiling / Brendan Fu-Long Sieow and Mahesh Uttamchandani -- Protein-protein interaction inhibitors of BRCA1 discovered using small molecule microarrays / Zhenkun Na, Sijun Pan, Mahesh Uttamchandani, and Shao Q. Yao -- Discovery of RNA binding small molecules using small molecule microarrays / Colleen M. Connelly, Fardokht A. Abulwerdi, and John S. Schneekloth, Jr. -- Profiling phosphopeptide-binding domain recognition specificity using peptide microarrays / Michele Tinti, Simona Panni, and Gianni Cesareni -- Validation procedure for multiplex antibiotic immunoassays using flow-based chemiluminescence microarrays / Verena Katharina Meyer, Daniela Meloni, Fabio Olivo, Erwin Märtlbauer, Richard Dietrich, Reinhard Niessner, and Michael Seidel -- Large-scale interaction profiling of protein domains through proteomic peptide-phage display using custom peptidomes / Moon-Hyeong Seo, Satra Nim, Jouhyun Jeon, and Philip M. Kim -- Synthetic glycan microarrays / Felix Broecker and Peter H. Seeberger -- Screening mammalian cells on a hydrogel : functionalized small molecule microarray / Biwei Zhu, Bo Jiang, Zhenkun Na, and Shao Q. Yao
Summary Small molecule microarrays (SMM) were introduced in 1999 and within just a short span of time, have established themselves as a vibrant next generation platform for high-throughput screening. Small Molecule Microarrays: Methods and Protocols consolidates a significant collection of examples, which serve to guide researchers toward ways in which SMM technology may be effectively deployed for multiplexed screening, drug discovery and ligand identification. The volume is organized into three sections covering microarray fabrication, imaging modes, and discovery approaches. The chapters cover a range of small molecule library types, ranging from synthetic combinatorial libraries to peptide and carbohydrate libraries, with lessons and techniques that can be widely applied. Written in the highly successful Methods in Molecular Biology series, format, chapters include introductions of their respective topics, lists of the requisite materials and reagents, step-by-step and readily reproducible laboratory protocols as well as vital tips on troubleshooting and advice on avoiding known pitfalls. Authoritative and cutting-edge, Small Molecule Microarrays: Methods and Protocols provides meticulous insights into the successful applications of SMM, by experts in the field. Building on this collection of knowledge, the volume seeks to inspire a future generation of microarray practitioners to propel this significant technology to even greater heights
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerProtocol, viewed December 8, 2016)
Subject Protein microarrays.
Carrier proteins.
Molecular genetics.
Protein Array Analysis -- methods
Carrier Proteins
Small Molecule Libraries -- chemistry
Small Molecule Libraries -- pharmacology
Microarray Analysis -- methods
Molecular Biology -- methods
Carrier proteins
Molecular genetics
Protein microarrays
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Uttamchandani, Mahesh, editor.
Yao, Shao Q., editor.
ISBN 9781493965847