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Title Chemical library design / edited by Joe Zhongxiang Zhou
Published [New York, N.Y.] : Humana Press, ©2011


Description 1 online resource (x, 362 pages) : illustrations
Series Methods in molecular biology, 1940-6029 ; v. 685
Methods in molecular biology (Clifton, N.J.) ; v. 685. 1064-3745
Contents Historical overview of chemical library design -- Chemoinformatics and library design -- Molecular library design using multi-objective optimization methods -- A scalable approach to combinatorial library design -- Application of free-Wilson selectivity analysis for combinatorial library design -- Application of QSAR and shape pharmacophore modeling approaches for targeted chemical library design -- Combinatorial library design from reagent pharmacophore fingerprints -- Docking methods for structure-based library design -- Structure-based library design in efficient discovery of novel inhibitors -- Structure-based and property-compliant library design of 11[beta]-HSD1 adamantyl amide inhibitors -- Design of screening collections for successful fragment-based lead discovery -- Fragment-based drug design -- LEAP into the Pfizer Global Virtual Library (PGVL) space: Creation of readily synthesizable design ideas automatically -- The design, annotation, and application of a kinase-targeted library -- PGVL hub: An integrated desktop tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds -- Design of targeted libraries against the human Chk1 kinase using PGVLhub -- GLARE: A tool for product-oriented design of combinatorial libraries -- CLEVER: A general design tool for combinatorial libraries
Summary Chemical library technologies have brought about dramatic changes in the drug discovery process, and, though still evolving, they have become an integral part of ongoing drug discovery research. In Chemical Library Design, experts in the field provide methods and detailed protocols delving into this key process of selecting useful, biologically relevant compounds from large pools of synthesizable candidates. This compendium includes chapters on historical overviews, state-of-the-art methodologies, including structure-based and fragment-based library design, practical software tools, and successful and important applications of chemical library design. As a volume in the popular Methods in Molecular Biology series, the thorough contributions provide the kind of meticulous description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Chemical Library Design is an ideal reference for all scientists seeking the technology needed to aid in the search for new and vital drugs
Analysis biochemie
chemische verbindingen
chemical compounds
Chemistry (General)
Chemie (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Combinatorial chemistry.
Drugs -- Design.
Chemistry -- methods
Combinatorial Chemistry Techniques -- methods
Drug Discovery -- methods
Small Molecule Libraries
Medical Informatics -- methods
Pharmaceutical Preparations -- chemistry
Drug Design
Combinatorial chemistry
Drugs -- Design
Genre/Form Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Zhou, Joe Zhongxiang
ISBN 9781607619314