| Description |
1 online resource (586 pages) |
| Contents |
Front cover; Preface; Editor; Contributors; Table of Contents; Part I. Comparative Structure and Function of the Skin; Chapter 1. Comparative Structure and Function of the Skin: Overview of Structures and Components; Chapter 2. Comparative Structure and Function of the Skin: Epithelial Basement Membrane Zone; Part II. Comparative Immunology; Chapter 3. Human Immune System; Chapter 4. Canine Immune System; Chapter 5. Rat Immune System; Chapter 6. Mouse Immune System; Part III. Immune Privilege and Skin Inflammation; Chapter 7. Immune Privilege of the Eye |
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Chapter 8. The Theory of Immune Privilege of the Hair FolliclePart IV. Methods of Experimental Animal Modeling; Chapter 9. Passive Transfer and Active Induction of Autoimmune Diseases; Chapter 10. Adoptive Transfer of Cellular Immunity; Chapter 11. Molecular Biological Manipulation of the Immune System by Transgenic Techniques; Part V. Inflammatory Skin Disease Models; Section A. Bullous Pemphigoid; Chapter 12. Natural Bullous Pemphigoid in Companion Animals; Chapter 13. Experimental Mouse Model of Bullous Pemphigoid: Passive Transfer of Anti-BP180 Type XVII Collagen, Antibodies |
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Section B. Epidermolysis Bullosa AcquisitaChapter 14. Spontaneous Canine Model of Epidermolysis Bullosa Acquisita; Section C. Mucous Membrane Pemphigoid; Chapter 15. Spontaneous Canine Model of Mucous Membrane Pemphigoid; Chapter 16. Experimental Mouse Model of Mucous Membrane Pemphigoid: Passive Transfer of Anti-Laminin 5 Antibodies; Section D. Pemphigus Vulgaris; Chapter 17. Spontaneous Canine Model of Pemphigus Vulgaris; Chapter 18. Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Desmoglein-Targeting Antibodies |
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Chapter 19. Experimental Mouse Model of Pemphigus Vulgaris: Passive Transfer of Nondesmoglein 1 and 3 AntibodiesSection E. Pemphigus Foliaceus; Chapter 20. Spontaneous Canine Model of Pemphigus Foliaceus; Chapter 21. Experimental Mouse Model of Pemphigus Foliaceus: Passive Transfer of Desmoglein-Targeting Antibodies; Section F. Psoriasis; Chapter 22. Experimental Chimeric SCID Mouse/Human Skin Model of Psoriasis: Induction by Transfer of Cellular Immunity; Chapter 23. Experimental Mouse Model of Psoriasis by Transgenic Expression of Integrin; Section G. Atopic Dermatitis |
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Chapter 24. Spontaneous Canine Model of Atopic DermatitisChapter 25. Spontaneous Mouse Model of Atopic Dermatitis in NC/Nga Mice; Chapter 26. Experimental Mouse Model of Atopic Dermatitis by Transgenic Induction; Chapter 27. Experimental Mouse Model of Atopic Dermatitis: Induction by Oral Allergen; Chapter 28. Experimental Mouse Model of Atopic Dermatitis: Induction by Epicutaneous Application of Allergen; Section H. Alopecia Areata; Chapter 29. Spontaneous and Experimental Skin-Graft-Transfer Mouse Models of Alopecia Areata |
| Summary |
Progress in understanding skin diseases has been aided enormously by the use of tissues derived from animals, by studying normal processes in animals, and by the development of animal models. The cellular activities in animals and humans are remarkably similar and the actual pathological process of an inflammatory skin disease can only be accurately observed and analyzed in a living animal model, and not in any in vitro model system. These factors have led to the regular use of animal tissues and models to allow the disease processes to be studied at a much greater depth. Animal Models of Human |
| Notes |
Chapter 30. Spontaneous Rat Model of Alopecia Areata in the Dundee Experimental Bald Rat (DEBR) |
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Print version record |
| Subject |
Alopecia areata.
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Skin -- Inflammation -- Animal models
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Alopecia Areata
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Alopecia areata
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| Form |
Electronic book
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| ISBN |
9781135510329 |
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1135510326 |
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