| Description |
1 online resource : illustrations |
| Contents |
880-01 Front Cover; Skin Tissue Engineering and Regenerative Medicine; Copyright; Dedication; Contents; List of Contributors; Foreword; 1 -- Anatomy, Physiology, Histology, and Immunohistochemistry of Human Skin; INTRODUCTION; SKIN ANATOMY, HISTOLOGY, AND PHYSIOLOGY; EPIDERMIS; Keratinocytes; Melanocytes; Langerhans Cells; Merkel Cells; DERMOEPIDERMAL JUNCTION; DERMIS; Vasculature; Muscles; Nerves; Skin Appendages; HYPODERMIS; WOUND HEALING AND IMMUNOHISTOCHEMISTRY; Wound Morphometrics; Immunohistochemistry to Define Elements within the Skin; REFERENCES |
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880-01/(S SAFETY FEATURES OF GENETICALLY MODIFIED SKIN TISSUE -- DESIGNER TISSUES FOR SPECIFIC NEEDS -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- 14 -- The Surgical Management of Burn Wounds -- EPIDEMIOLOGY OF BURN INJURIES -- PRESENTATION OF BURN INJURIES -- RESUSCITATION -- Wound Care -- REPAIR -- Excision -- Autografts -- Allografts -- Xenografts -- Dermal Substitutes -- REFERENCES -- 15 -- Advances in Isolation and Expansion of Human Cells for Clinical Applications -- INTRODUCTION -- SKIN HARVESTING -- CELL ISOLATION -- CELL EXPANSION -- CLINICAL APPLICATION -- CONCLUSION -- REFERENCES -- 16 -- Cutaneous Applications of Stem Cells for Skin Tissue Engineering -- INTRODUCTION: STEM CELLS -- SKIN-DERIVED STEM CELLS -- ADULT STEM CELLS -- Bone Marrow-Derived Stem Cells -- Adipose-Derived Stem Cells -- PERINATAL TISSUES AND STEM CELLS -- Amniotic Membrane -- Placental MSCs -- Amnion Epithelial Cells -- Amniotic Fluid Stem Cells -- SUMMARY AND FUTURE APPLICATIONS OF STEM CELLS IN WOUND HEALING -- REFERENCES -- 17 -- Advances in Biopharmaceutical Agents and Growth Factors for Wound Healing and Scarring -- INTRODUCTION -- THE TRANSFORMING GROWTH FACTOR-Β FAMILY -- OTHER TGF-Β-BASED APPROACHES: DECORIN AND MANNOSE 6 PHOSPHATE -- MODULATION OF SMAD3/SMAD7 SIGNALING -- EPIDERMAL GROWTH FACTOR FAMILY -- FIBROBLAST GROWTH FACTOR FAMILY -- PLATELET-DERIVED GROWTH FACTOR FAMILY -- GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR -- CONNECTIVE TISSUE GROWTH FACTOR -- HEPATOCYTE GROWTH FACTOR -- INTERLEUKIN 10 -- CONNEXINS -- OTHER APPROACHES UNDER INVESTIGATION FOR SCAR REDUCTION -- DISCUSSION AND FUTURE DIRECTIONS -- LIST OF ABBREVIATIONS -- REFERENCES -- 18 -- Skin Models for Drug Development and Biopharmaceutical Industry -- OUTLINE OF THE CHAPTER -- INTRODUCTION -- Basic Considerations -- Target and Hit Identification and Validation |
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2 -- Molecular and Cellular Biology of Wound Healing and Skin RegenerationINTRODUCTION; Normal Adult Wound Healing; Scarless Fetal Healing; Scarless Wound Healing in/ he Adult; FIBROPROLIFERATIVE DISORDERS OF/ HE SKIN; Cellular Basis of HTS; Molecular Basis of HTS; Lessons Learned from Preclinical Porcine Models of Abnormal/ kin Healing; MEDICAL THERAPIES FOR SKIN REGENERATION; Commercially Available Tissue-Engineered Skin Solutions/ or HTS; Recent Developments/ n Dermal Engineering; FUTURE DIRECTIONS; LIST OF ABBREVIATIONS; ACKNOWLEDGMENTS; REFERENCES |
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3 -- Tissue Processing and Staining for Histological AnalysesINTRODUCTION; TISSUE FIXATION; TISSUE PROCESSING AND EMBEDDING; HEMATOXYLIN AND EOSIN STAIN; BRIGHT FIELD MICROSCOPY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; Antibodies Commonly Used/ or Skin Disorders; HISTOCHEMICAL STAINS; Trichrome Stain; GMS Stain (Methenamine/ ilver-Grocott's); Phosphotungstic Acid-Hematoxylin, Mallory's; PAS Stain (McManus' Periodic Acid-Schiff's); Elastic Tissue Fibers-Verhoeff's Van Gieson; Acid-Fast Bacteria-Ziehl-Neelsen Stain; CONCLUSION; REFERENCES |
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4 -- Clinical Management of Wound Healing and Hypertrophic ScarringWOUND HEALING AND THE BIOMEDICAL BURDEN OF ITS DYSFUNCTION; STAGES OF WOUND HEALING; PATHOLOGIC WOUND HEALING; CHRONIC WOUNDS; WOUND HEALING THERAPIES; Negative Pressure Therapy; Cytokines and Growth Factors; Cell-Based Therapy; Biomimetic Scaffolds; FIBROPROLIFERATIVE DISEASE; SCAR REDUCTION THERAPIES; General Approaches; Scar Revision Surgery; Radiotherapy; Laser Therapy; Cryotherapy; Moisture-Retaining Dressings; Antiproliferative Agents; Anti-inflammatory Therapies; Reducing Mechanical Tension; REGENERATIVE HEALING |
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CONCLUSIONLIST OF ABBREVIATIONS; REFERENCES; 5 -- Process Development and Manufacturing of Human and Animal Acellular Dermal Matrices; INTRODUCTION; CLINICAL NEED; DEVELOPMENT OF ADMS; ADM REQUIREMENTS; PROCESSING METHODOLOGIES; Tissue Acquisition; Animal Dermis; Human Dermis; Decellularization Techniques; Physical Methods; Chemical Methods; Detergents; Acids or Bases; Hypotonic or Hypertonic Treatments; Alcohol and Other Solvents; Biologic Methods; Decellularization Criteria; Crosslinking; Preservation of ADMs; Wet Preservation; Cryopreservation; Freezing; Lyophilization; Sterilization |
| Summary |
The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed January 20, 2016) |
| Subject |
Tissue engineering.
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Skin -- Regeneration
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Regenerative medicine.
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Tissue Engineering
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Regenerative Medicine
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Regenerative medicine
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Tissue engineering
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| Form |
Electronic book
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| Author |
Albanna, Mohammad Z., editor
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Holmes, James H., editor
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| ISBN |
9780128017975 |
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012801797X |
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012801654X |
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9780128016541 |
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