| Description |
1 online resource (194 pages) |
| Contents |
Intro -- Contents -- Chapter 1: Can We End Melanoma As We Know It? The Role of Early Detection in Defeating Deadly Skin Cancer -- Introduction -- Case -- Additional Clinical History -- Melanoma Risk Factors -- Physical Exam Findings -- Discussion -- Critical Take Home Messages -- References -- Chapter 2: Melanoma Risk Factors and Prevention -- Introduction -- Case -- Melanoma Disparities -- Risk Factors -- Phenotypic Features -- Personal Medical History -- Genetic Predisposition/Family History -- Environmental Factors -- Screening -- Prevention -- Discussion of Case -- Conclusions |
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Mutational Load -- Sentinel Lymph Nodes (SLN) -- Discussion of Case -- Conclusions -- References -- Chapter 4: Melanoma Epidemiology, Staging and Prognostic Factors -- Introduction -- Melanoma Epidemiology -- Melanoma Staging -- Prognostic Factors in Melanoma -- Depth of Invasion -- Ulceration -- Mitotic Rate -- Growth Phase and Melanoma Subtypes -- Regression -- Tumor Infiltrating Lymphocytes -- Lymphatic Invasion and Angiotropism -- Neurotropism -- Nevus Association -- Age -- Gender -- Marital Status -- Anatomical Location -- Tumor Derived Markers -- Molecular Markers of Melanoma Prognosis |
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Conditional Survival -- Summary -- References -- Chapter 5: Imaging in Melanoma -- Lymphoscintigraphy for Sentinel Node Biopsy -- Lymphoscintigraphy Technique -- Possible Radiation Risk of LS -- Potential Problems with LS -- Wide Local Excision (WLE) -- Reproducibility -- The Melanoma Site Immediately Overlies a Node Field -- Conclusion -- Ultrasound in Melanoma Patients -- Diagnosis -- Patient Case -- Does US Have a Role in Primary Assessment of Melanoma? -- Staging -- Case Continued -- What Are the US Criteria for Defining Normal and Abnormal Lymph Nodes? |
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What Is the Role of US Assessment of the Regional Lymph Node Basins Before Sentinel Node Mapping and/or Biopsy? -- Follow Up -- Case Continued -- How Is US Used in Follow Up? -- Conclusion -- Cross Sectional Imaging -- Staging -- Early Stage Disease -- Later Stage Disease -- Monitoring the Effects of Therapy -- Post Treatment Surveillance -- Effect on Survival -- Conclusion -- References -- Chapter 6: Primary Melanoma Treatment -- Case -- Introduction -- Operative Primary Melanoma Treatment -- Wide Excision -- Technique -- Recommended Margins for Wide Excision -- Clinical vs Pathologic Margins |
| Summary |
This book provides a practically applicable resource for all clinicians managing patients with or who may develop melanoma. Each chapter focuses on clinically relevant information on the latest advances in the field, including techniques for early detection of skin cancers, cross-sectional imaging and staging of regional nodes. Algorithms for clinical decision-making along with clinical vignettes are incorporated into each chapter, enabling the reader to develop a deep understanding of how to manage a range of scenarios. Practical Manual for Dermatologic and Surgical Melanoma Management systematically details the latest diagnostic criteria, treatment guidelines and management techniques available for treating these patients and is a valuable resource for the trainee and practising clinician |
| Bibliography |
References-Chapter 3: The Laboratory Evaluation of Melanoma-Introduction-Case-Histopathology-Immunohistochemistry-Diagnostic IHC-Prognostic and Therapeutic IHC-BRAF and MEK-c-Kit-Immune Checkpoints (CTLA4/PD-1/PD-L1)-Molecular Assays-Comparative Genomic Hybridization (CGH) and Single Nucleotide Polymorphism (SNP) Arrays-Fluorescence in Situ Hybridization (FISH)-Molecular Assays-Diagnostic/Prognostic-RNA-Base Gene Expression Profiling (Quantitative Reverse Transcription Polymerase Chain Reaction-qRT-PCR)-Liquid (Serologic) Biomarkers |
| Notes |
Areas of Uncertainty |
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Print version record |
| Subject |
Skin -- Cancer -- Treatment -- Handbooks, manuals, etc
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Skin -- Cancer -- Surgery -- Handbooks, manuals, etc
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Disease management.
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Melanoma -- diagnosis
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Melanoma -- therapy
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Disease Management
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Skin -- Cancer -- Surgery
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| Genre/Form |
handbooks.
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Handbooks and manuals
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Handbooks and manuals.
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Guides et manuels.
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| Form |
Electronic book
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| Author |
Lee, Delphine J
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Faries, Mark B
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| ISBN |
9783030274009 |
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3030274004 |
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