Historical overview of X-linked mental retardation / Turner -- Clinical features of the Fragile X syndrome / Hagerman, Smith, Mariner -- Cytogenetic aspects of the Fragile X syndrome / McGavran and Maxwell -- The heterozygous female / Hagerman and Smith -- Genetic counseling in the Fragile X syndrome / Smith and Berry -- Biochemistry of the Fragile X syndrome / Taylor and Hagerman -- Behavioral dysfunction in the Fragile X syndrome / Levitas, McBogg, Hagerman -- Speech and language dysfunction in the Fragile X syndrome / Newell, Sanborn, Hagerman -- Treatment and intervention / Hagerman and McBogg -- Appendix A. Expression of the Fragile X media requirements, processing and analysis -- Appendix B. Explanation of assessment tools for speech and language evaluation