Title Architects of structural biology : Bragg, Perutz, Kendrew, Hodgkin / John Meurig Thomas

Edition First edition Published Oxford, United Kingdom ; New York, NY : Oxford University Press, 2020

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Description 1 online resource Summary Designed for the non-specialist, the explanations and illustrations used here describe the work, personalities, collaborations, and idiosyncrasies of four of the most distinguished Nobel Laureates of the twentieth century. They exploited a discovery made over a century ago about the nature of X-rays, and thereby created a new branch of science. This enabled them to elucidate, in atomic detail, the structure and mode of action of molecules of the living world: enzymes, vitamins, and viruses, as well as antibiotics. Perutz and Kendrew, from their pioneering work using X-ray diffraction on haemoglobin and myoglobin, the proteins that transport and store oxygen in all animals, led them to establish in 1962 one of the most successful research centres ever - the Laboratory of Molecular Biology (LMB) in Cambridge. Medicines discovered there are used worldwide to treat leukaemia, arthritis, and other diseases. Their work also led to the creation in the United States of the Protein Data Bank that guides scientists in understanding the misfolding of proteins, which cause Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. This book is first a memoir of these scientists and their contemporaries, many of them friends of the author. Second, it is an insight into the great excitement associated with structural molecular biology, which directly informs our understanding of ourselves. Third, it describes how two renowned research centres in the United Kingdom - the LMB and the Davy-Faraday Research Laboratory - achieved iconic status. It also highlights the importance of the popularization of science, of which Bragg, Perutz, and Kendrew, as well as Dorothy Hodgkin (who solved the structures of penicillin and vitamin B12) were experts Notes Includes index Online resource, title from PDF title page (Oxford Scholarship Online, viewed March 25, 2020) Subject Bragg, William Henry, 1862-1942. Perutz, Max F. Kendrew, John C. (John Cowdery), 1917-1997. Hodgkin, Dorothy, 1910-1994. SUBJECT Bragg, William Henry, 1862-1942 fast Hodgkin, Dorothy, 1910-1994 fast Kendrew, John C. (John Cowdery), 1917-1997 fast Perutz, Max F. fast Subject Laboratory of Molecular Biology -- History SUBJECT Laboratory of Molecular Biology fast Subject Scientists -- Great Britain -- History -- 20th century Molecular biology -- History -- 20th century Proteins -- Structure -- Research -- History -- 20th century Molecular biology Scientists Great Britain Genre/Form Electronic books History Form Electronic book ISBN 9780192596710 0192596713 9780191888793 0191888796

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