Title Reverse transcriptase inhibitors in HIV/AIDS therapy / edited by Gail Skowron, Richard Ogden ; foreword by Joep M.A. Lange

Published Totowa, N.J. : Humana Press, ©2006

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Description 1 online resource (xiii, 527 pages) : illustrations Series Infectious disease Infectious disease (Totowa, N.J.) Contents Structural studies on HIV reverse transcriptase related to drug discovery / David K. Stammers and Jingshan Ren -- Zidovudine, lamivudine, and abacavir / Monica Carten and Harold Kessler -- Stavudine, didanosine, and zalcitabine / Gail Skowron, Sapna Chowdhry and Michael R. Stevens -- Emtricitabine / Gail Skowron, Jeffrey Bratberg and Rudi Pauwels -- Nucleotide analogs / Craig J. Hoesley -- Resistance to nucleoside and nucleotide reverse transcriptase inhibitors / Nancy Shulman and Mark Winters -- Pharmacokinetics of reverse transcriptase inhibitors / Patrick Hoggard [and others] -- Peripheral neuropathy associated with nucleoside reverse transcriptase inhibitor therapy / Bruce A. Cohen and Russell Bartt -- Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: a pathophysiological perspective / William Lewis -- Mitochondrial toxicity and lipodystrophy / Grace McComsey -- Nevirapine / David Asmuth and Richard Pollard -- Efavirenz / Graeme J. Moyle and Brian Conway -- Delavirdine / Brian Conway -- Resistance to non-nucleoside reverse transcriptase inhibitors / F. Ramzi Asfour and Richard Haubrich -- Vertical transmission of HIV and therapeutic interventions / Susan Cu-Uvin, Arlene Bardeguez and Carla Chibwesha -- New reverse transcriptase inhibitors in development / Rudi Pauwels -- Antiretroviral drugs for millions / Allan Ronald, Ellie Katabira and Merle Sande Summary Despite significant pharmacological advances, the backbone of the most highly active antiretroviral therapy regimens for controlling HIV/AIDS is still a combination of reverse transcriptase inhibitors (RTIs) first discovered in the late 1980s. In Reverse Transcriptase Inhibitors in HIV/AIDS Therapy, leading experts in AIDS/HIV drug discovery and development review all aspects of RTIs (nucleosides, nucleotides, and non-nucleosides), including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment in general, and on vertical transmission in the developing world. Highlights include a thorough discussion of side effects, resistance, and treatment in the third world. Comprehensive and up-to-date, Reverse Transcriptase Inhibitors in HIV/AIDS Therapy offers a magisterial survey of the discovery, clinical development, current use, and future possibilities of all drugs that treat HIV/AIDS by inhibiting the viral reverse transcriptase Bibliography Includes bibliographical references and index Notes English In Springer e-books Subject AIDS (Disease) -- Chemotherapy HIV infections -- Chemotherapy Reverse transcriptase inhibitors -- Therapeutic use Antiretroviral agents. HIV infections. Reverse transcriptase. Acquired Immunodeficiency Syndrome -- drug therapy HIV Infections -- drug therapy Reverse Transcriptase Inhibitors -- therapeutic use Anti-Retroviral Agents Anti-HIV Agents HIV Infections RNA-Directed DNA Polymerase MEDICAL -- AIDS & HIV. HEALTH & FITNESS -- Diseases -- AIDS & HIV. Reverse transcriptase -- Inhibitors -- Therapeutic use. Antiretroviral agents. Acquired Immunodeficiency Syndrome -- drug therapy. HIV Infections -- drug therapy. Reverse Transcriptase Inhibitors -- therapeutic use. AIDS (Disease) -- Chemotherapy. HIV infections -- Chemotherapy. Reverse transcriptase HIV infections AIDS (Disease) -- Chemotherapy Antiretroviral agents HIV infections -- Chemotherapy Form Electronic book Author Skowron, Gail. Ogden, Richard C., 1953- LC no. 2005033190 ISBN 1588296490 1597450855 9781597450850 9781588296498

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