| Description |
1 online resource : illustrations (some color) |
| Series |
Essentials in ophthalmology, 2196-890X |
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Essentials in ophthalmology.
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| Contents |
Preface; Contents; Contributors; 1: Molecular Biology of Retinoblastoma; 1.1 The First Tumor Suppressor; 1.2 Structural Biology of the Rb Pathway; 1.2.1 The RB1 Gene; 1.2.2 The Rb Phosphorotein; 1.3 Functions of the Rb Pathway; 1.3.1 Regulation of E2F-Responsive Gene Transcription; 1.3.2 Epigenetic Effects, Including Active Repression of Other Genes Through Chromatin Remodeling; 1.3.3 Cell Cycle Inhibition; 1.3.4 Maintenance of Cellular Differentiation; 1.3.5 Anti-apoptotic Function; 1.3.6 Maintenance of Chromosomal Stability; 1.4 Disruption of the Rb Pathway |
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1.4.1 Modulation of Rb Phosphorylation State1.4.2 Viral Oncoproteins; 1.4.3 Epigenetics and Imprinting; 1.5 Clinical Importance of Retinoblastoma Molecular Genetics; 1.5.1 Heritability; 1.5.2 Second Primary Tumors; 1.5.3 Age of Onset; 1.5.4 Retinocytoma and Low Penetrance Retinoblastoma; 1.5.5 Vitreous Seeding; 1.5.6 Future Treatments; 1.6 Conclusion; References; 2: Challenges of Genetic Susceptibility Testing for Retinoblastoma; 2.1 Introduction; 2.2 Definition of Genetic Counseling; 2.3 Referrals for Genetic Counseling in Retinoblastoma Clinics |
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2.4 Elements of Genetic Counseling2.5 Components of Pre-test Genetic Counseling; 2.6 Genetic Testing and Types of RB1 Results; 2.7 Potential Risks of RB1 Testing; 2.8 Explanation of the Potential Benefits and Uses of RB1 Genetic Testing; 2.9 Referral to Prenatal Genetic Counselor and Options for Prenatal Testing; 2.10 Explanation of the Limitations of RB1 Genetic Testing; 2.11 Case Scenarios; 2.12 Other Considerations of RB1 Testing; 2.13 Components of Post-test Genetic Counseling; 2.14 Conclusion; References; 3: Technique of Ophthalmic Artery Chemosurgery for Retinoblastoma |
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3.1 Introduction3.2 Material and Methods; 3.2.1 Patient Population; 3.2.2 Protocol; 3.2.3 Intra-arterial Chemotherapy Procedure; 3.3 Results; 3.4 Conclusion; References; 4: Vitreous Disease and the Technique, Safety and Toxicity of Intravitreal Chemotherapy for Retinoblastoma; 4.1 Vitreous Disease; 4.1.1 Dust; 4.1.2 Spheres; 4.1.3 Clouds; 4.2 Technique; 4.2.1 History; 4.2.2 Safety Enhancement; 4.2.3 Decreasing Needle Size and Volume of Drug; 4.2.4 Lowering Intraocular Pressure; 4.2.5 Injection Site Precautions; 4.2.6 Exclusion Criteria; 4.2.7 Irrigation/Water Submersion |
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4.2.8 Ocular and Needle Washings4.2.9 Tethered Seeds; 4.3 Ocular Toxicity; 4.3.1 Electroretinogram: Clinical; 4.3.2 Electroretinogram: Preclinical; 4.3.3 Clinical Signs of Toxicity; 4.4 Systemic Toxicity; 4.5 Conclusion; References; 5: Electroretinogram Monitoring of Retinoblastoma Treatment; 5.1 Introduction; 5.2 Ophthalmic Artery Chemotherapy Infusion; 5.3 ERG Protocol; 5.4 ERG Testing Schedule; 5.5 ERG Recording During Examination Under Anesthesia: Technical Considerations; 5.5.1 Baseline Noise; 5.5.2 Effect of Ocular Manipulation on the ERG |
| Summary |
This comprehensive resource on the current understanding of retinoblastoma addresses all of the essential aspects of retinoblastoma and its management, including: its molecular biology and genetics, management by intraarterial and intravitreal chemotherapy, electroretinogram monitoring of treatment, pharmacokinetic studies, high-risk features, treatment of metastatic disease, and long-term follow-up. The book represents a collaborative project involving ophthalmic oncologists, geneticists, pediatric oncologists, interventional neuroradiologists, electrophysiologists, and basic scientists who are at the forefront of their field. It is written in an accessible manner, and a wealth of tables, figures, and exemplary images are included to enhance the understanding of concepts |
| Analysis |
pediatrie |
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paediatrics |
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geneeskunde |
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medicine |
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volksgezondheid |
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public health |
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oogheelkunde |
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ophthalmology |
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oncologie |
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oncology |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Notes |
"The chapters in this book represent most of the lectures that were delivered at the elebration honoring 100 years of retinoblastoma in New York (1914-2014)"--Preface |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (Ebsco, viewed July 28, 2015) |
| Subject |
Retinoblastoma -- Treatment
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Retinoblastoma -- therapy
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HEALTH & FITNESS -- Diseases -- Cancer.
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MEDICAL -- Oncology.
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MEDICAL -- Pediatrics.
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Medicine
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Oncology
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Ophthalmology
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Pediatrics
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| Form |
Electronic book
|
| Author |
Francis, Jasmine H., editor
|
|
Abramson, David H., editor.
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| ISBN |
9783319194677 |
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3319194674 |
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3319194666 |
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9783319194660 |
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