| Description |
1 online resource (xxxi, 324 pages) : illustrations |
| Contents |
1. Respiratory control disorders: from genes to patients and back / David Gozal -- 2. Hereditary aspects of respiratory control in health and disease in humans / John V. Weil -- 3. Phox2b and the homeostatic brain / Jean-François Brunet and Christo Goridis -- 4. Congenital central hypoventilation syndrome: from patients to gene discovery / Ha Trang -- 5. Structural and functional brain abnormalities in congenital central hypoventilation syndrome / Ronald M. Harper [and others] -- 6. In vitro study of Pho2xb gene mutations in congenital central hypoventilation syndrome / Tiziana Bachetti and Isabella Ceccherini -- 7. Sudden infant death syndrome: study of genes pertinent to cardiorespiratory and autonomic regulation / Debra E. Weese-Mayer [and others] -- 8. The genetic basis for obstructive sleep apnea: what role for variation in respiratory control? / Susan Redline, Sanjay R. Patel -- 9. Apnea and irregular breathing in animal models: a physiogenomic approach / Motoo Yamauchi [and others] -- 10. Genetic determinants of respiratory phenotypes in mice / Clarke G. Tankersley -- 11. Genes and development of respiratory rhythm generation / Jean Champagnat [and others] -- 12. Transcription factor control of central respiratory neuron development / Bruno C. Blanchi and Michael H. Sieweke -- 13. Lessons from mutant newborn mice with respiratory control deficits / Claude Gaultier -- 14. Tentative mouse model for the congenital central hypo-ventilation syndrome: heterozygous Phox2b mutant newborn mice / Jorge Gallego [and others] -- 15. Respiratory control abnormalities in necdin-null mice: implications for the pathogenesis of Prader-Willi syndrome / John J. Greer and Rachel Wevrick -- 16. Possible role of bioaminergic systems in the respiratory disorders of Rett syndrome / John Bissonnette and Gerard Hilaire -- 17. Respiratory plasticity following intermittent hypoxia: a guide for novel therapeutic approaches to ventilatory control disorders? / Gordon s Mitchell |
| Summary |
This book provides an overview of the recent advances in the genetics of respiratory control in health and disease. The objective of the book is to bring together top-level contributions on all aspects of the genetics of respiratory control. These include molecular aspects of respiratory neurodevelopment from embryonic to postnatal life, molecular biology of human respiratory control disorders, and interactions between genetics and plasticity in respiratory control. The book will also show how combined studies in humans and mouse models have helped to improve our understanding of the mechanism |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer e-books |
| Subject |
Respiratory organs -- Diseases.
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Respiratory Tract Diseases -- genetics
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Models, Animal
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Respiratory Tract Diseases -- therapy
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MEDICAL -- Pulmonary & Thoracic Medicine.
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HEALTH & FITNESS -- Diseases -- Respiratory.
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Respiratory organs -- Diseases -- Treatment.
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Respiratory Tract Diseases -- genetics.
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Models, Animal.
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Respiratory Tract Diseases -- therapy.
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Respiratory organs -- Diseases.
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Biomédecine.
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Sciences de la vie.
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Respiratory organs -- Diseases
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| Form |
Electronic book
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| Author |
Gaultier, C. (Claude)
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| ISBN |
9780387707655 |
|
0387707654 |
|
9780387707648 |
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0387707646 |
|
