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Title Synthetic nucleic acids as inhibitors of gene expression : mechanisms, applications, and therapeutics implications / edited by Levon Michael Khachigian
Published Boca Raton : CRC Press, ©2005


Description 1 online resource (182 pages) : illustrations (some color)
Contents Therapeutic application of ribozymes for cardiovascular disease -- Development of ribozymes as cancer therapeutics -- RNA interference: a technology based on an ancient gene silencing pathway -- RNA-cleaving DNA enzymes in gene silencing: room for improvement? -- Deoxyribozymes and medical innovation -- Effect of modifications on the intracellular activity of a DNA enzyme -- Potential therapeutic applications of DNA enzymes and siRNAs against viral and cellular genes -- Use of DNAzymes for target gene validation -- DNAzymes targeting immediate-early genes as inhibitors of angiogenesis and restenosis -- Decoy oligodeoxynucleotides as viable pharmaceutical drugs
Summary "This book brings together timely, authoritative reviews by renowned international leaders in the fields of ribozymes, RNA interference, DNAzymes and oligonucleotide decoys, with emphasis on biochemistry and translational research. The chapters on ribozymes include discussions of ribozyme subtypes, structure-function aspects, and therapeutic applications: those on DNAzymes, their various subtypes, kinetics and biochemistry, and applications in target validation. Finally, the mechanisms and multiple therapeutic applications of double-stranded oligonucleotide decoys are described."
"For readers ranging from graduate students to researchers seeking target validation for pharmaceuticals to clinicians seeking innovative cancer, cardiovascular and other therapies, no resource is more complete and up to date."--Jacket
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Catalytic RNA.
Repressors, Genetic.
Genetic regulation.
Nucleic Acids -- physiology
Nucleic Acids -- therapeutic use
DNA, Catalytic
Gene Silencing -- drug effects
RNA, Catalytic
Repressor Proteins
Gene Expression Regulation
SCIENCE -- Life Sciences -- Molecular Biology.
BIOGRAPHY & AUTOBIOGRAPHY -- Science & Technology.
Catalytic RNA
Genetic regulation
Repressors, Genetic
Form Electronic book
Author Khachigian, Levon
LC no. 2004054474
ISBN 1420037897