| Description |
1 online resource (499 p.) |
| Series |
Advances in Biochemistry in Health and Disease ; v.25 |
|
Advances in biochemistry in health and disease ; v. 25.
|
| Contents |
Intro -- Preface -- Contents -- Contributors -- Part I General Implications of RAS in Infectious and Other Diseases -- 1 Implications of Renin-Angiotensin System in Health and Disease -- Introduction -- Functional Components of RAS as Targets for Pharmacologic Manipulation -- Involvement of RAS in Liver Disease -- Involvement of RAS in Respiratory Syndrome Coronavirus Infection -- Participation and Significance of RAS in Heart Failure -- Concluding Remarks -- References -- 2 The Interplay of the Renin-Angiotensin System and Solid Organ Transplantation -- Introduction |
|
Complications of Solid Organ Transplantation -- Recent Efforts to Mitigate IRI -- Historical Perspective of the RAS -- Renin-Angiotensin System (RAS) Molecular Mechanisms -- RAS in Liver Disease -- OLT Modulates RAS -- RAS and Alterations in Immune Pathways and Gut Microbiome -- RAS/Microbiome in Health and Disease -- Future Considerations -- Conclusion -- References -- 3 Correlation Between Renin Angiotensin System and Infectious Disease -- Renin Angiotensin System (RAS) -- Classical Pathway RAS -- Non-classical Pathway RAS -- Renin -- ACE -- ACE2 -- Angiotensin II -- Ang (1-9), Ang (1-7) |
|
RAS-Acting Pharmacological Agents -- RAS and Infectious Lung Disease -- RAS Dysfunction and Development of Acute Lung Injury (ALI) -- Role of RAS in ALI Caused by Avian Influenza Virus Infections H5N1 e N7N9 -- Hand, Foot and Mouth Disease (HFMD) -- Role of RAS in ALI Caused by SARS-CoV Coronavirus Infections -- Role of RAS in ALI Caused by Coronavirus Infections SARS-CoV-2 -- Could A Pharmacological Approach That Modulates the RAS be of Clinical Benefit to Combat Lung Damage from Respiratory Infections? -- Conclusions -- References |
|
4 Emerging Contributions of Endocrine Pathophysiology in Virus-Related Infectious Disease: Focus on the RAAS in COVID-19 and HIV -- Introduction -- Understanding the RAAS in Health and Dysregulated States -- Traditional Use of RAAS Blockers -- Where SARS-CoV-2 and HIV Meet -- SARS-CoV-2 and the RAAS -- RAAS Dysregulation and Organ Dysfunction in COVID-19 -- Therapeutic Targets and Trials in COVID-19 -- Future Directions in COVID-19 -- HIV and the RAAS -- RAAS Dysregulation and Organ Dysfunction in HIV -- Therapeutic Targets and Trials in HIV -- Future Directions in HIV -- Conclusion -- References |
|
5 Understanding the Renin-Angiotensin System in Coronavirus Disease 2019 -- Introduction -- Angiotensin-Converting Enzyme -- RASS Pathway -- Hypertension -- SARS-COV-2 and ACE2 in Lungs -- SARS-COV-2 and ACE2 in Heart -- Other Organs and Tissue Injuries -- Pancreas -- Skeletal Muscles -- Central Nervous System -- Blood Vessels -- Potential Targets and Drugs -- Inaccuracies and a Strong Urge to Act -- Conclusion -- References -- 6 Metabolomics Approach in Differentiating RAS Responses in ARDS and SAR-CoV-2 -- Introduction -- SARS-CoV-2 Interaction with the RAS |
| Summary |
This book of the series on Advances in Biochemistry in Health and Disease includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world |
| Notes |
Application of RAS Components in Relation to SARS-CoV-2-Related Morbidities |
|
Online resource; title from PDF title page (SpringerLink, viewed March 22, 2023) |
| Subject |
Renin-angiotensin system -- Pathophysiology
|
|
Hormone therapy.
|
|
Hormone Replacement Therapy
|
|
Hormone therapy
|
| Form |
Electronic book
|
| Author |
Bhullar, Sukhwinder K.
|
|
Tappia, Paramjit S.
|
|
Dhalla, Naranjan S.
|
| ISBN |
9783031236211 |
|
3031236211 |
|
