| Description |
1 online resource (xix, 399 pages) : illustrations (some color) |
| Series |
Victor Chang molecular cardiology series, 1561-4409 ; v. 1 |
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Victor Chang molecular cardiology series ; v. 1. 1561-4409
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| Contents |
Part I Physiology of Angiotensin II 1 -- Chapter 1 The Renin-Angiotensin System and Cardiovascular Homeostasis / M.C. Chappell, E.A. Tallant, D.I. Diz, C.M. Ferrario 3 -- Chapter 2 Angiotensin II Receptors in Central Nervous System Physiology / M.I. Phillips 27 -- Chapter 3 Current Opinions on the Involvement of Angiotensin II in Hydromineral Balance / P.J. Mulrow 53 -- Chapter 4 Angiotensin II Effects on Reproductive Biology: Physiology or Pharmacological Curiosity? / E.R. Lumbers 67 -- Chapter 5 Physiological Insights Derived from Mapping the Distributions of Angiotensin Receptors / A.M. Allen, J. Zhuo, C. Maric, S.Y. Chai, F.A.O. Mendelsohn 93 -- Part II Molecular Basis for Angiotensin II Receptor Structure, Function and Regulation 115 -- Chapter 6 Conformational Theories on Receptor Activation from Studies of the AT[subscript 1] Receptor / S.S. Karnik 117 -- Chapter 7 Control of Angiotensin II Action Through Receptor Regulation / W.G. Thomas 137 -- Part III Elucidation of Pathophysiological Mechanisms Through ACE Inhibition, AT[subscript 1] Receptor Antagonism and Gene Knockouts 157 -- Chapter 8 Clinical Applications and Limitations in the use of AT[subscript 1]-Receptor Antagonists / B. Waeber, H.R. Brunner 159 -- Chapter 9 Implications for the Pathophysiology of Hypertension and Heart Failure Derived from Clinical Experience with Drugs Modifying the Renin-Angiotensin System / I.B. Squire, J.L. Reid 175 -- Chapter 10 Clinical Trials of ACE Inhibitors: Pathogenetic Insights and Therapeutic Advances / L.M. Burrell, C.I. Johnston 191 -- Chapter 11 Targeted Interruption of the Renin-Angiotensin System / D. Ertoy, K.E. Bernstein 205 -- Part IV Angiotensin-Forming Enzymes: Biochemistry, Cellular and Molecular Biology 229 -- Chapter 12 Renin Secretion: Old Concepts and New Theories / I.A. Reid 231 -- Chapter 13 Understanding the Regulation of Renin Gene Expression Through in vitro and in vivo Models / P.L. Sinn, C.D. Sigmund 259 -- Chapter 14 Three-Dimensional Structure and Substrate Specificity of Renin / V. Dhanaraj 283 -- Chapter 15 Regulation of ACE Expression: One Gene, Two Enzymes / S.P. Kessler, I. Sen, G.C. Sen 303 -- Chapter 16 ACE in the Normal and Injured Heart: Where, What and Why? / K.T. Weber, Y. Sun 325 -- Chapter 17 Chymase: A Critical Evaluation of its Role in Angiotensin II Formation and Cardiovascular Disease / L. J. Dell'Italia, A. Husain 347 -- Chapter 18 Kallikrein: Physiological Role in Angiotensin Formation / M. Sasaguri, K. Arakawa 367 |
| Summary |
Since 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the renin -- angiotensin system has been the forerunner of clinical approaches to cardiovascular diseases using molecular tools. Drugs, Enzymes and Receptors of the Renin -- Angiotensin System is designed to highlight molecular and clinical approaches to understanding the renin -- angiotensin system |
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Chapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and unique feature of this book is that a commentary on each chapter, written by an independent peer or peers, is included to present alternative views, greater depth and a different perspective. Clinicians and researchers alike will find this volume a stimulating, and perhaps even entertaining, addition to their libraries |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Angiotensin II -- Physiological effect
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Renin-angiotensin system.
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Cardiovascular system -- Pathophysiology
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Renin-Angiotensin System -- physiology
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Renin-Angiotensin System
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Cardiovascular Diseases -- physiopathology
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MEDICAL -- Cardiology.
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Angiotensin II -- Physiological effect.
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Renin-Angiotensin System.
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Cardiovascular system -- Pathophysiology.
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Renin-Angiotensin System -- physiology.
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Cardiovascular Diseases -- physiopathology.
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Cardiovascular system -- Pathophysiology
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Renin-angiotensin system
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| Form |
Electronic book
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| Author |
Husain, Ahsan
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Graham, Robert M
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Victor Chang Cardiac Research Institute.
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| ISBN |
0203304527 |
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9780203304525 |
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9780429179433 |
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042917943X |
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