Title The local cardiac renin angiotensin-aldosterone system / edited by Edward D. Frohlich and Richard N. Re

Published New York : Springer, ©2006

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Description 1 online resource (xvi, 224 pages) : illustrations Series Basic science for the cardiologist ; 20 Basic science for the cardiologist ; 20. Contents Preface / Edward D. Frohlich, Richard N. Re -- Hypertensive heart disease : time for new paradigms / Edward D. Frohlich -- Cardiac (PRO) renin receptors : functional properties and potential significance / Genevieve Nguyen, A.H. Jan Danser -- On the relationship between the renin receptor and the vacuolar proton-ATPase membrane sector-associated protein (M8-9) / Nathalie L'Huillier [and others] -- Role of the AT₂ receptor in cardiovascular function : a brief synopsis / Robert M. Carey, Helmy M. Siragy -- Reciprocal regulation of renin in JGA and tubules in hypertension / L. Gabriel Navar [and others] -- Salt loading a paradigm for a local cardiac renin-angiotensin-aldosterone System / Jasmina Varagic -- Lessons from experimental generation of intracellular angiotensinogen and A11 / Julia L. Cook, Richard N. Re -- On the cardiac renin angiotensin system : the heart as a source of angiotensin II / Walmor C. De Mello -- The hematopoietic system : a new niche for the renin-angiotensin system / Christine Hubert [and others] -- Mechanical signaling and the cardiac renin-angiotensin / Sandhya Sanghi, David E. Dostal -- Angiotensin converting enzyme 2 : a critical regulator of the renin-angiotensin system / Patricia E. Gallagher, Ann Tallant, Carlos M. Ferrario -- Dyslipidemia and angiotensin II and atherogenesis / Muhammad T. Gill, Jaiwei Chen, J.L. Mehta -- ACE inhibitors directly activate bradykinin B₁ receptors to release NO / Tatjana Ignjatovic [and others] -- Remodeling in hypertensive heart disease : role of the renin-angiotensin-aldosterone system / Arantxa Gonzhlez [and others] -- Cardiac aldosterone production : a vascular problem? / Bernard Swynghedauw, Christophe Heyrnes, Claude Delcayre -- Cellular oxidative stress, aging and the local RAS / Leon F Fader Summary How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. However, it wasn't until the simultaneous finding by two different geographically separated teams, Page, et al, in the United States and Braun-Menendez, et al, in Argentina that the peptide angiotensin was identified. Thus, the rate-limiting enzyme renin was released from the kidney and catalyzed a biochemical cascade which was eventually shown to produce the elevated arterial pressure. Subsequently, many workers contributed to the elucidation of the concept and sequence of angiotensin I1 generation. Thus, the enzyme renin acted upon its protein substrate, produced in the liver, to liberate the decapeptide angiotensin I which, upon circulating through the pulmonary circulation, finally produced the potent octapeptide angiotensin. Several important subsequent findings demonstrated that angiotensin I1 promoted the release of the adrenal corticosteroid from that gland, thereby resulting in a larger system, the renin-angiotensin-aldosterone system. Further, this system demonstrated a classical biofeedback and the circulating octapeptide was shown to have additional biological activities in organs other than heart, vessels, kidney, adrenals, and even brain Bibliography Includes bibliographical references and index Notes Print version record In Springer e-books Subject Renin-angiotensin system. Heart -- Physiology. Renal hypertension. Renin. Renin-Angiotensin System -- physiology Renin-Angiotensin System Hypertension, Renal Renin Hypertension -- metabolism Receptors, Cell Surface -- physiology Vacuolar Proton-Translocating ATPases -- metabolism MEDICAL -- Physiology. SCIENCE -- Life Sciences -- Human Anatomy & Physiology. Heart -- Physiology. Renal hypertension. Renin. Renin-Angiotensin System -- physiology. Hypertension -- metabolism. Receptors, Cell Surface -- physiology. Vacuolar Proton-Translocating ATPases -- metabolism. Renin-Angiotensin System. Heart -- Physiology Renal hypertension Renin Renin-angiotensin system Genre/Form Electronic books Form Electronic book Author Frohlich, Edward D., 1931- Re, Richard Noel ISBN 0387278257 9780387278254 0387278265 9780387278261 6610460450 9786610460458

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