Description |
1 online resource (xviii, 866 pages) : illustrations |
Contents |
Title Page; Copyright Page; Preface; Table of Contents; Contributors; Chapter 1 Physiology of erythropoiesis; Ontogenesis of erythropoiesis; Basic mechanisms in the control of erythropoiesis; Role of EPO, EPO-R, Kit Ligand and c-kit in the control of erythropoiesis; Molecular mechanisms of control of erythropoiesis: role of transcription factors; Anti-apoptotic mechanisms operating in erythroid cells; Role of apoptosis in the control of erythropoiesis; Role of AKT pathway in the apoptotic control of the erythroid lineage |
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Further signaling pathways involved in the apoptotic regulation of erythroid cellsSummary; References; Chapter 2 Biology of EPO and EPO-receptor; Introduction; Role of EPO in erythropoiesis; Regulation of EPO production; Structure of the EPO receptor; EPO-induced intracellular signalling; Pathways leading to signalling arrest; Acknowledgements; References; Chapter 3 The role of erythropoietin receptor expression on tumor cells; Introduction; Does EPO cause proliferation of tumor cells in vitro?; What does the detection of EPO receptors on tumor cell mean?; Concluding remarks; Acknowledgements |
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Hematological characteristicsShortened red blood cell survival; Impaired iron utilization; Suppressed erythroid progenitor cells; Inadequate erythropoietin production; Summary; References; Chapter 7 Prevalence and incidence of anemia and risk factors for anemia in patients with cancer; Definition of anemia; Anemia in cancer; Prevalence of anemia in cancer; Risk factors for prediction of anemia; Acknowledgement; References; Chapter 8 Significance of anemia in cancer chemotherapy; Introduction; Incidence; Pathophysiology; Predictive factors; Prognostic significance; Conclusion; References |
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Chapter 9 Incidence and impact of anemia in radiation oncologyIntroduction; Frequency of anemia; Prognostic impact of anemia; Explanations for the prognostic impact of anemia; References; Chapter 10 Relationship between hemoglobin levels and tumor oxygenation*; Introduction; Tumor hypoxia and anemia as adverse prognostic factors; Relationship between hemoglobin level and tumor oxygenation: animal studies; Relationship between hemoglobin level and tumor oxygenation: clinical observations; Conclusions; Addendum; Acknowledgement; References; Chapter 11 Tumor hypoxia and therapeutic resistance* |
Summary |
Anemia, a frequent complication of cancer and its treatments, produces unwanted symptoms and significantly impairs metabolic and physiologic functions, as well as patients' activity, quality of life and even life expectancy. In its new Second Edition, this book presents current knowledge on anemia in cancer and its treatment with Recombinant Human Erythropoietin (rhEPO). Expanded, updated and newly added chapters describe scientific and clinical aspects of anemia, and give diagnostic and therapeutic recommendations on use of rhEPO. This is an essential source of information for radiotherapists |
Analysis |
geneeskunde |
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medicine |
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volksgezondheid |
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public health |
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radiotherapie |
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radiotherapy |
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hematologie |
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haematology |
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chirurgie |
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surgery |
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farmacologie |
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pharmacology |
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toxicologie |
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toxicology |
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bloedtransfusie |
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blood transfusion |
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oncologie |
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oncology |
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Medicine (General) |
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Geneeskunde (algemeen) |
Bibliography |
Includes bibliographical references and index |
Notes |
Print version record |
Subject |
Recombinant erythropoietin -- Therapeutic use
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Anemia -- Chemotherapy
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Cancer -- Chemotherapy -- Complications.
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Anemia -- physiopathology
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Erythropoietin, Recombinant -- therapeutic use
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Anemia -- complications
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Erythropoietin -- therapeutic use
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Neoplasms -- complications
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Anemia -- Chemotherapy
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Cancer -- Chemotherapy -- Complications
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Recombinant erythropoietin -- Therapeutic use
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Form |
Electronic book
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Author |
Nowrousian, M. R
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ISBN |
9783211694596 |
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3211694595 |
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3211252231 |
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9783211252239 |
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