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Title Death receptors and cognate ligands in cancer / Holger Kalthoff, ed
Published Heidelberg ; New York : Springer, ©2009


Description 1 online resource (xiii, 280 pages) : illustrations
Series Results and problems in cell differentiation, 0080-1844 ; 49
Results and problems in cell differentiation ; 49.
Contents The role of TNF in cancer / Harald Wajant -- Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses / Madhu Ramaswamy [and others] -- FasL expression and reverse signaling / M. Lettau [and others] -- Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling / Stefan Schütze and Wulf Schneider-Brachert -- Ubiquitination and TNFR1 signaling / Ken-ichi Fujita and Srinivasa M. Srinivasula -- From biochemical principles of apoptosis induction by TRAIL to application in tumour therapy / Stefanie M. Cordier, Kerstin Papenfuss, and Henning Walczak -- Therapeutic targeting of TWEAK/Fn14 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway / Jennifer S. Michaelson and Linda C. Burkly -- APRIL in B-cell malignancies and autoimmunity / Fiona C. Kimberly, Jan Paul Medema, and Michael Hahne -- Autophagy in cancer and chemotherapy / Shida Yousefi and Hans-Uwe Simon -- Glucocorticoid-mediated apoptosis resistance of solid tumors / Ingrid Herr, Markus W. Büchler, and Jürgen Mattern -- Targeting death-receptors in radiation therapy / Olivier Niemöller and Claus Belka -- Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands / Jeannette Gerspach, Harald Wajant, and Klaus Pfizenmaier
Summary Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling path
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Cell receptors -- Physiological effect
Carcinogenesis -- Molecular aspects.
Cancer -- Treatment.
Tumor necrosis factor -- Physiological effect
Tumor necrosis factor -- Receptors -- Physiological effect
Receptors, Tumor Necrosis Factor -- physiology
Neoplasms -- etiology
Neoplasms -- therapy
Receptors, Death Domain -- physiology
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Sciences de la vie.
Cancer -- Treatment
Carcinogenesis -- Molecular aspects
Krebs Medizin
Ligand Biochemie
Genre/Form Aufsatzsammlung.
Form Electronic book
Author Kalthoff, Holger.
ISBN 9783642030451