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Title TNF receptor associated factors (TRAFs) / edited by Hao Wu
Published New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2007


Description 1 online resource (xix, 206 pages) : illustrations (some color)
Series Advances in experimental medicine and biology, 0065-2598 ; v. 597
Advances in experimental medicine and biology ; v. 597. 0065-2598
Contents Phylogeny of the TRAF/math domain / Juan M. Zapata, Vanesa Martínez-García, and Sophie Lefebvre -- TRAF1 and its biological functions / Soo Young Lee and Yongwon Choi -- Physiological roles and mechanisms of signaling by TRAF2 and TRAF5 / Ping-Yee Billie Au and Wen-Chen Yeh -- TRAF3 and its biological function / Jeannie Q. He [and others] -- TRAF4, the unique family member / Valérie Kedinger and Marie-Christine Rio -- Characteristics and biological functions of TRAF6 / Jun-ichiro Inoue, Jin Gohda and Taishin Akiyama -- Ubiquitination and TRAF signaling / Gabriel Pineda, Chee-Kwee Ea and Zhijian J. Chen -- Structural revelations of TRAF2 function in TNF receptor signaling pathway / Jee Y. Chung [and others] -- Protein-protein interactions in TRAF3 / Kathryn R. Ely, Ramadurgam Kodandapani and ShuangDing Wu -- Molecular basis for the unique specificity of TRAF6 / Jee Y. Chung [and others]
TRAF proteins in CD40 signaling / Gail A. Bishop [and others] -- TRAFs in rank signaling / Bryant G. Darnay [and others] -- The LT[beta]R signaling pathway / Paula S. Norris and Carl F. Ware -- LMP1 trafficking activates growth and survival pathways / Vishal Soni, Ellen Cahir-McFarland and Elliott Kieff -- Targeting TRAFs for therapeutic intervention / Juan M. Zapata, Sophie Lefebvre and John C. Reed
Summary It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embryonic development, innate and adaptive immune regulation and maintenance of cellular homeostasis. Agents that manipulate the signaling of these receptors are being used or showing promise towards the treatment and prevention of many human diseases such as rheumatoid arthritis, coronary heart disease, transplantation rejection, insulin resistance, multiple organ failure and cancer. TNF Receptor Associated Factors is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection. TNF Receptor Associated Factors is intended for a wide audience, including researchers in the field of TRAF signaling and students and postdoctoral fellows learning cell biology and cell signal transduction. This exciting new volume is up to date on the most recent advances in TRAF signal transduction
Analysis celbiologie
cellular biology
Cellular Biology
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer eBooks
Subject Tumor necrosis factor -- Receptors.
Cellular signal transduction.
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins -- physiology
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor -- metabolism
Signal Transduction
Tumor Necrosis Factors -- metabolism
MEDICAL -- Immunology.
Cellular signal transduction.
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins -- physiology.
Receptors, Tumor Necrosis Factor -- metabolism.
Signal Transduction.
Tumor Necrosis Factors -- metabolism.
Tumor necrosis factor -- Receptors.
Sciences de la vie.
Cellular signal transduction
Tumor necrosis factor -- Receptors
Form Electronic book
Author Wu, Hao, Dr.
LC no. 2007013602
ISBN 9780387706306