Title DHEA and the brain / edited by Robert Morfin

Published London ; New York : Taylor & Francis, 2002

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Description 1 online resource (xiv, 204 pages) : illustrations Series Nutrition, brain, and behavior ; v. 1 Nutrition, brain, and behavior ; v. 1. Contents Cover -- Nutrition, brain and behaviour -- DHEA and the Brain -- Contents -- Contributors -- Series preface -- Preface -- Chapter 1 The brain, a putative source and target of DHEA -- NEUROSTEROID: THE CONCEPT AND ITS IMPLICATIONS -- REGULATION OF PREGNENOLONE AND DHEA, SYNTHESIS/ACCUMULATION IN RAT BRAIN TISSUE -- DHEA IN HUMANS -- CONCLUDING REMARKS -- REFERENCES -- Chapter 2 DHEA metabolites during the life span -- INTRODUCTION -- DHEA/S DURING LIFE AND THE IMPORTANCE OF STEROID SULFATASE -- DHEA METABOLISM -- 7-OXYGENATED DHEA METABOLITES -- PHYSIOLOGICAL LEVELS OF 7-OH-DHEA ISOMERS AND AGEING -- 7-OXO-DHEA -- 16-HYDROXYLATED METABOLITES OF DHEA -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 3 Postulated roles of DHEA in the decline of neural function with age -- INTRODUCTION -- THE LIFE HISTORY OF DHEA -- DHEA AS A NEUROSTEROID -- MEASURING DHEA IN THE BLOOD, BRAIN AND SALIVA -- DHEA: EXPERIMENTAL EFFECTS ON BEHAVIOR -- DHEA AND CORTISOL -- DHEA AND BRAIN FUNCTION IN MAN -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4 DHEA: hormone of youth and resilience -- still a maverick -- INTRODUCTION: THE NEUROSTEROIDS -- DHEAS AS EXCITATORY NEUROMODULATOR -- DHEA AS HORMONE OF MENTAL HEALTH -- DHEA(S) IN MEMORY AND AGEING -- DHEA/S AND SEXUAL DIMORPHISM -- DHEA/S REPLACEMENT -- CONCLUSION -- REFERENCES -- Chapter 5 DHEA effects on liver -- INTRODUCTION -- PHARMACOKINETICS, UPTAKE AND METABOLISM OF DHEA(S) -- ALTERATIONS IN ENERGY METABOLISM -- PEROXISOME PROLIFERATION -- OXIDATIVE STRESS AND LIPID PEROXIDATION -- HEPATOCARCINOGENIC EFFECT OF DHEA -- MODULATION OF HEPATOCARCINOGENESIS BY DHEA -- ANTICARCINOGENIC EFFECT OF DHEA -- CONCLUSION -- REFERENCES -- Chapter 6 DHEA and brain development -- DEFINITION OF A NEUROSTEROID -- ENZYMES INVOLVED IN THE SYNTHESIS OF DHEA -- DISTRIBUTION OF P450scc AND P450c17 IN THE BRAIN AND REGULATION OF THEIR EXPRESSION DURING DEVELOPMENT -- DEVELOPMENTAL ROLE OF DHEA AND DHEAS IN ORGANOGENESIS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 7 DHEA metabolism in the brain: production and effects of the 7a-hydroxylated derivative -- INTRODUCTION -- 7a-HYDROXYLATION OF DHEA IN MOUSE, RAT AND HUMAN BRAIN -- INVOLVEMENT OF CYP7B1 IN BRAIN -- ROLE OF P450 7B1 AND SUBSTRATE SPECIFICITY -- CYP7B1 IN HUMAN HIPPOCAMPUS -- NEUROPROTECTION AND P450 7B1 ACTIVITY -- CONCLUDING REMARKS -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 8 DHEA: biosynthesis, regulation and function in the central nervous system -- INTRODUCTION -- DHEA -- BIOSYNTHESIS OF DHEA -- DHEA IN NORMAL AND PATHOLOGICAL BRAIN FUNCTION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 9 Cross-talk between DHEA and neuropeptides -- INTRODUCTION -- PEPTIDES MODULATING DHEA/DHEAS SYNTHESIS -- DHEA/DHEAS AND APPETITE MODULATING PEPTIDES -- DHEA/DHEAS, PEPTIDES, AND CALORIC INTAKE -- SEARCH FOR A LINK -- REFERENCES -- Chapter 10 DHEA effects on human behavior and psychiatric illness -- INTRODUCTION -- ASSOCIATION BETWEEN DHEA/S LEVEL AND MOOD, COGNITION, AND FUNCTIONAL ABILITIES IN NORMAL INDIVIDUALS -- BEHAVIORAL EFFECTS OF DHEA ADMINISTRATION IN NORMAL INDIVIDUALS -- tid Summary In this book the authors evaluate existing studies and discuss new ideas and approaches to future investigations into the physiological actions of this hormone Bibliography Includes bibliographical references and index Notes Print version record Subject Dehydroepiandrosterone. Dehydroepiandrosterone -- Physiological effect Brain chemistry. Nootropic agents. Dehydroepiandrosterone -- metabolism Dehydroepiandrosterone -- physiology Dehydroepiandrosterone Brain -- drug effects Brain Chemistry Nootropic Agents Receptors, Steroid -- agonists MEDICAL -- Pain Medicine. MEDICAL -- Psychiatry -- Psychopharmacology. Nootropic agents Brain chemistry Dehydroepiandrosterone Dehydroepiandrosterone -- Physiological effect Form Electronic book Author Morfin, Robert LC no. 2005279630 ISBN 0203301218 9780203301210 1280022019 9781280022012

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