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E-book

Title Pain therapeutics : current and future treatment paradigms / [edited by] Charlotte Allerton, David Fox
Published [Cambridge] : Royal Society of Chemistry, 2013

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Description 1 online resource
Series RSC drug discovery ; volume 35
RSC drug discovery series ; v. 35.
Contents Fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; fig1; _s_h_o_w_10_; _s_h_o_w_223_; _s_h_o_w_260_; _s_h_o_w_312_; _s_h_o_w_330_; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig2; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig3; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig4; fig5; fig5; fig6; fig6; fig5; fig5; fig6
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Summary This book presents a contemporary review of the field of Pain Therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets from pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific changes in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally the book covers the discovery and development stories for two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, will give insight into the discovery and development challenges and successes for both an oral and non-oral product
Notes English
Publisher supplied information
Subject Analgesics.
Diseases.
Senses and sensation.
Neurologic manifestations of general diseases.
Psychophysiology.
Neurotransmitter receptors.
Nervous system -- Diseases.
Cell receptors.
Membrane proteins.
Proteins.
Pain.
Opioids -- Receptors.
Anti-inflammatory agents.
Neurotransmitters.
Nervous System Physiological Phenomena
Disease
Therapeutic Uses
Sensory System Agents
Sensation
Receptors, G-Protein-Coupled
Neurologic Manifestations
Receptors, Neuropeptide
Signs and Symptoms
Molecular Mechanisms of Pharmacological Action
Central Nervous System Agents
Physiological Effects of Drugs
Pharmacologic Actions
Receptors, Peptide
Psychophysiology
Receptors, Neurotransmitter
Pathological Conditions, Signs and Symptoms
Peripheral Nervous System Agents
Nervous System Diseases
Receptors, Cell Surface
Chemical Actions and Uses
Psychological Phenomena and Processes
Membrane Proteins
Proteins
Chemicals and Drugs
Psychiatry and Psychology
Musculoskeletal and Neural Physiological Phenomena
Amino Acids, Peptides, and Proteins
Phenomena and Processes
Pain
Receptors, Opioid
Anti-Inflammatory Agents
Neurotransmitter Agents
Analgesics
protein.
Chemistry.
MEDICAL -- Pharmacology.
Analgesics.
Form Electronic book
Author Allerton, Charlotte, editor
Fox, David, editor
ISBN 9781849737715
1849737711