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Title Advances in rapid sex-steroid action : new challenges and new chances in breast and prostate cancers / Gabriella Castoria, Antimo Migliaccio, editors
Published New York, NY : Springer, ©2012


Description 1 online resource (xvii, 268 pages) : illustrations
Contents Non genomic action of steroid hormones: more questions than answers -- Part I: Breast Cancer -- Progesterone signaling to chromatin in breast cancer cells. two initial cycles of remodeling -- Cooperative interactions between c-Src, estrogen receptors, and receptor tyrosine kinases in breast cancer -- Cross talk between ERa and Src signaling and its relevance to ER status and hormone responsiveness -- Post-translational modifications of ER alpha in rapid estrogens' action -- Sex-steroid rapid action and its role in invasiveness and metastasis of breast cancer -- Unraveling the role of GPER in breast cancer -- Nongenomic actions of estrogens and xenoestrogens affecting¬° endocrine cancer cells -- Part II: Prostate Cancer -- Androgen receptor pathway in prostate cancer: old target and new drugs -- Differential functions of stromal and epithelial androgen receptor in prostate cancer before and after castration resistant stage -- Role of androgens and androgen receptor in prostate cancer: genomic and non-genomic actions -- Mechanisms of signal transduction in prostate cancer: the role of PI3-kinase pathway in androgen action -- The IGF-1 axis in prostate cancer: the role of rapid steroid actions -- Part III: New tools for steroid receptor analysis and regulatory networks -- Quantitative visualization of sex steroid receptor functions: AR and ERa -- Micropatterned surfaces as tools for the study of rapid non-genomic actions of steroid receptors. Index
Summary Annotation This book examines how rapid steroid actions not only impact disease development and response to conventional therapies for breast and prostate cancers, but have also led to the identification of potential new therapeutic targets and treatment possibilities
Analysis Medicine
Cancer Research
Biomedicine general
Bibliography Includes bibliographical references and index
In Springer eBooks
Subject Hormones, Sex -- Receptors.
Hormones, Sex -- Carcinogenicity
Steroid hormones -- Therapeutic use.
Breast -- Cancer -- Chemotherapy
Prostate -- Cancer -- Chemotherapy
Cell receptors.
Gonadal Steroid Hormones -- therapeutic use
Receptors, Cell Surface
Breast Neoplasms
Prostatic Neoplasms
Drug Therapy
MEDICAL -- Pharmacology.
Cell receptors
Breast -- Cancer -- Chemotherapy
Hormones, Sex -- Carcinogenicity
Hormones, Sex -- Receptors
Prostate -- Cancer -- Chemotherapy
Steroid hormones -- Therapeutic use
Form Electronic book
Author Castoria, Gabriella
Migliaccio, Antimo
LC no. 2011941855
ISBN 9781461417644