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Title Histamine receptors as drug targets / edited by Ekaterini Tiligada, Madeleine Ennis
Published New York, NY : Humana Press : Springer, ©2017


Description 1 online resource (xvi, 517 pages) : illustrations (some color)
Series Methods in pharmacology and toxicology, 1557-2153
Methods in pharmacology and toxicology, 1557-2153
Contents Methodologies to identify and analyze genetic polymorphisms for human histamine receptors / Stephany Micallef and Astrid Sasse -- Development, characterization, and validation of anti-human H3 receptor isoform-specific antibodies / Fiona C. Shenton, Natasha Lethbridge, and Paul L. Chazot -- Approaches to recombinant histamine H3/H4 receptor expression in mammalian cells / Tadeusz Karcz, Urszula Cichoń, and Katarzyna Kieć-Kononowicz -- Histamine H2 receptor biased signaling methods / Natalia C. Fernández, Carina Shayo, Carlos Davio, and Federico Monczor -- Ligand-binding kinetics on histamine receptors / Reggie Bosma, Tamara A.M. Mocking, Rob Leurs, and Henry F. Vischer -- Methods to study the molecular pharmacology of the histamine H4 receptor / Eléonore W.E. Verweij, Rob Leurs, and Henry F. Vischer -- Chemiluminescence : a sensitive method for detecting the effects of histamine receptor agonists/antagonists on neutrophil oxidative burst / Ondřej Vašíček, Tomáš Perečko, Viera Jančinová, Silvia Pažoureková, Radomír Nosáľ, and Milan Číž -- Techniques used in pharmacological evaluation of histamine H4 receptor function on native human eosinophils / Marek Grosicki and Katarzyna Kieć-Kononowicz -- Assessment of the efficacy of histamine receptor antagonists in murine models of atopic dermatitis / Kristine Rossbach, Hanna Köchling, Tomoki Fukuyama, Jenny Wilzopolski, Manfred Kietzmann, and Wolfgang Bäumer -- Methodological approaches to study histamine pharmacology in the kidney : from cell culture and cell imaging to functional assays and electron microscopy / Alessandro Pini, Eleonora Veglia, Cristina Grange, and Arianna Carolina Rosa -- Histamine and the kidney : in vivo animal models / Alessandro Pini, Eleonora Veglia, and Arianna Carolina Rosa -- Methodological approaches to investigate the effects of histamine receptor targeting compounds in preclinical models of breast cancer / Diego J. Martinel Lamas, Melisa B. Nicoud, Helena Sterle, Graciela P. Cricco, Gabriela A. Martin, Graciela A. Cremaschi, Hubert G. Schwelberger, Elena S. Rivera, and Vanina A. Medina -- Evaluation of histidine decarboxylase (HDC) activity and human histamine receptor 3 (H3R) and HDC mRNA levels / Carlos Acosta-Andrade, José L. Urdiales, Ignacio Fajardo, and Francisca Sánchez-Jiménez -- Cerebrospinal fluid markers in neuroinflammation : the paradigm of optic neuritis / Dimitrios P. Besinis and Maria C. Anagnostouli -- In vivo diagnostic procedures for IgE-mediated allergic disorders / Christopher Koulias, Xenophon Aggelides, Caterina Chliva, and Michael Makris -- Dermatological indications of antihistamines / Chrysovalantis Korfitis, Efstathios Rallis, and Dimitrios Rigopoulos -- Histamine quantification in human blood samples / Ekaterini Tiligada, Maria Kakolyri, and Madeleine Ennis
Summary This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the decision gates that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques. Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerProtocol, viewed March 9, 2017)
Subject Histamine -- Receptors.
Receptors, Histamine -- therapeutic use
Histamine Antagonists -- pharmacology
Models, Animal
Receptors, Histamine
Medical -- Pharmacology.
Genre/Form Laboratory manuals
Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Tiligada, Ekaterini, editor
Ennis, Madeleine, editor
ISBN 9781493968435