Title Tissue-specific estrogen action : novel mechanisms, novel ligands, novel therapies / K.S. KOrach, T. Wintermantel, editors

Published Berlin ; New York : Springer, ©2007

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Description 1 online resource (xv, 181 pages) : illustrations (some color) Series Ernst Schering Foundation symposium proceedings, 0947-6075 ; 2006/1 Ernst Schering Foundation symposium proceedings ; 2006/1. 0947-6075 Contents Interfering with the dynamics of estrogen receptor-regulated transcription / S. Johnsen, S. Kangaspeska, G. Reid and F. Gannon -- Actions of estrogen and estrogen receptors in nonclassical target tissues / E. Murphy and K.S. Korach -- Genetic dissection of estrogen receptor signaling in vivo / T. Wintermantel, J. Elzer, A. Herbison, K.-H. Fritzemeier and G. Schütz -- Of mice and men: the many guises of estrogens / E.R. Simpson and M.E. Jones -- Estradiol action in atherosclerosis and reendothelialization / J.- F. Arnal, H. Laurell, F. Lenfant, V. Douin-Echinard, L. Brouchet and P. Gourdy -- Functional effects and molecular mechanisms of subtype-selective ER[alpha] and ER[beta] agonists in the cardiovascular system / P.A. Arias-Loza, V. Jazbutyte, K.-H. Fritzemeier, C. Hegele-Hartung, L. Neyses, G. Ertl and T. Pelzer -- Pathogenesis and therapy of rheumatoid athritis / R.O. Williams -- The role of ER[alpha] and ER[beta] in the prostate: insights from genetic models and isoform-selective ligands / S.J. McPherson, S.J. Ellem, V. Patchev, K.H. Fritzemeier and G.P. Risbridger -- Preclinical characterization of selective estrogen receptor [beta] agonists: new insights into their therapeutic potential / H.A. Harris -- Exploiting nongenomic estrogen receptor-mediated signaling for the development of pathway-selective estrogen receptor ligands / C. Otto, S. Wessler and K.-H. Fritzemeier Summary Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled "The Second Decade" and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand) binding to gene expression changes. In nuclear receptor molecular biology, estrogen receptor research has additional unique facets: since the discovery of ethinyl estradiol by Inhoffen and Hohlweg in the laboratories of Schering AG in the 1930s--and therefore several decades longer than nuclear receptor - searchitself--estrogenreceptorshavebeentargetsofwidelyused, orally administered drugs. Thus, accumulating clinical experience on estrogen action in vivo helps to support the progress in molecular biological research Bibliography Includes bibliographical references Notes English Print version record In Springer e-books Subject Estrogen -- Receptors -- Congresses Estrogen -- Mechanism of action -- Congresses Estrogen -- Therapeutic use -- Congresses Estrogen -- Receptors. Estrogen -- Therapeutic use. Estrogens -- metabolism Estrogens -- therapeutic use Receptors, Estrogen -- metabolism Receptors, Estrogen Estrogen Replacement Therapy MEDICAL -- Reproductive Medicine & Technology. HEALTH & FITNESS -- Women's Health. Estrogens -- therapeutic use. Receptors, Estrogen -- metabolism. Estrogen -- Receptors. Estrogen -- Mechanism of action. Estrogen -- Therapeutic use. Estrogens -- metabolism. Estrogen -- Receptors Estrogen -- Therapeutic use Genre/Form proceedings (reports) Conference papers and proceedings Conference papers and proceedings. Actes de congrès. Form Electronic book Author Korach, Kenneth S. Wintermantel, Tim. ISBN 9783540495475 3540495479 9783540495482 3540495487 1280864702 9781280864704 9786610864706 6610864705

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