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Title Estrogen receptor and breast cancer : celebrating the 60th anniversary of the discovery of ER / Xiaoting Zhang, editor
Published Cham, Switzerland : Humana Press, [2019]


Description 1 online resource : illustrations
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Introduction: On the discovery of Estrogen Receptor Sohaib Khan Physiological and Pathological Roles of Estrogen Receptor Ken Korach Estrogen Receptor Cofactors Bert O'Malley Estrogen Receptor Pioneer Factors and Cistrome Myles Brown/Jason Carroll Estrogen Receptor Transcriptome Benita S Katzenellenbogen Long Range Enhancer Regulation of ER Target Genes Rosenfeld MG/Glass C Estrogen Receptor Regulation of microRNAs Ken Nephew First Targeted Therapy -- History of Tamoxifen Craig Jordan Selective Estrogen Receptor Modulators (SERMs) McDonnell DP Anti-estrogen Therapies in Clinical Practices Carols Arteaga Structural Insights into ER and Anti-Estrogen Therapies Geoff Greene Molecular Mechanisms of Endocrine Resistance CK Osborne Estrogen Receptor Mutants in Breast Cancer Susan Fuqua Estrogen Receptor Beta and Breast Cancer Gustafsson JA Xenoestrogens, Phytoestrogens and Breast Cancer Nira Ben-Jonathan Emerging Approaches to Overcome Endocrine Resistance Xiaoting Zhang (with Future Perspective)
Summary The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed October 19, 2018)
Subject Estrogen -- Receptors.
Estrogen -- Therapeutic use.
Breast -- Cancer -- Hormone therapy
Receptors, Estrogen
Estrogen Replacement Therapy
Medical research.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Breast -- Cancer -- Hormone therapy.
Estrogen -- Receptors.
Estrogen -- Therapeutic use.
Form Electronic book
Author Zhang, Xiaoting, editor
ISBN 9783319993508