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Title Current immunotherapeutic strategies in cancer / Matthias Theobald, editor
Published Cham, Switzerland : Springer, [2020]


Description 1 online resource (v, 187 pages) : illustrations (some color)
Series Recent results in cancer research, 2197-6767 ; volume 214
Recent results in cancer research ; 214. 0080-0015
Contents Current development of monoclonal antibodies in cancer therapy -- Clinical experience with bispecific T-cell engagers -- Advances and challenges of CAR-modified T cells in clinical trials -- Targeting cancer with genetically engineered TCR-T cells -- Tailored vaccines based on patient's cancer mutanome -- Next-generation checkpoint inhibitors and immune agonists
Summary "This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient's cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment"--Publisher's description
Bibliography Includes bibliographical references
Notes Online resource; title from electronic title page (ProQuest Ebook Central, viewed on February 23, 2021)
Subject Cancer -- Immunotherapy.
Precision medicine
Neoplasms -- drug therapy
Antibodies, Monoclonal -- therapeutic use
Receptors, Antigen, T-Cell
Precision Medicine
Neoplasms -- therapy
Precision medicine
Cancer -- Immunotherapy
Form Electronic book
Author Theobald, Matthias, editor.
ISBN 9783030237653