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Book Cover
E-book

Title Razoxane and dexrazoxane - two multifunctional agents : experimental and clinical results / Walter Rhomberg, Kurt Hellmann, editors
Published Dordrecht ; London : Springer, 2010

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Description 1 online resource : v.: digital
Contents Preface; Acknowledgments; Contents; Contributors; 1 Introduction; 2 Razoxane; 3 Dexrazoxane; 4 Summary and Outlook; Index
Summary "Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer's disease could be stabilized by one or both these drugs."--Page 4 of cover
Analysis neoplasms
radiotherapie
radiotherapy
geneeskunde
medicine
biomedische wetenschappen
biomedicine
oncologie
oncology
cardiologie
cardiology
neurowetenschap
neuroscience
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Antineoplastic agents -- Development.
Cancer -- Chemotherapy.
Razoxane
Dexrazoxane
Antineoplastic Agents -- pharmacology
Razoxane -- pharmacology
Neoplasms -- drug therapy
MEDICAL -- Pharmacology.
Biom├ędecine.
Sciences de la vie.
Antineoplastic agents -- Development.
Cancer -- Chemotherapy.
Form Electronic book
Author Rhomberg, Walter.
Hellmann, K. (Kurt)
ISBN 9789048191680
9048191688