Pathology of aging rats : a morphological and experimental study of the age-associated lesions in aging BN/Bi, WAG/Rij, and (WAG x BN)F₁ rats / author, Joe D. Burek
Published
Boca Raton, FL : CRC Press, 2018
[Place of publication not identified] : CRC Press LLC : CRC Press, 2018
Cover; Title Page; Copyright Page; The Author; Acknowledgements; TABLE OF CONTENTS; Part I: Introduction; Chapter 1 Introduction; I. Purpose; II. Definition of an ""Old"" Rat; Ill. Lesions of Aging Rats; IV. Factors that can Influence Life Span Studies; V. Introduction to the Chapters; Part II: Background Information; Chapter 2 Background of the Animals and the Rat Colony; I. Background of the Rats; II. Colony Husbandry; A. Germ-free Colony; B. Specific Pathogen-free Breeding and Stock Colony; C. Aging Colony; III. Diet; IV. Breeding Performance and Preweanling Mortality
v. Weights of Aging RatsVI. Protocol for Sick or Dead Rats; VII. Necropsy Procedure; VIII. Selection of Necropsied Rats; Part III: Results and Discussion; Chapter 3 Longevity Studies; I. Longevity of Cohorts of Aging Rats; A. Cohorts of Virgins; B. Cohorts of Retired Breeders; II. Longevity of the Necropsied Rats; III. Discussion; Chapter 4 Age-associated Pathology; I. Introduction; II. Organs and Organ Systems; A. Thyroid Gland; 1. Nonneoplastic Lesions; 2. Neoplastic Lesions; a. Medullary Thyroid Carcinoma; b. Follicular Cell Tumors; 3. Discussion; B. Parathyroid Gland
1. Nonneoplastic Lesionsa. Interstitial Fibrosis; b. Cystic Parathyroid Glands; 2. Neoplastic Lesions; a. Parathyroid Adenomas; 3. Discussion; C. Adrenal Gland; 1. Nonneoplastic Lesions; a. Foci of Cellular Alteration in the Adrenal Cortex; b. Foci of Basophilic Change in the Adrenal Medulla; c. Blood-filled Sinuse and Cysts; d. Miscellaneous Nonneoplastic Findings; 2. Neoplastic Lesions; a. Cortical Adenomas; b. Cortical Carcinomas; c. Pheochromocytomas of the Adrenal Medulla; 3. Discussion; D. Pituitary Gland; 1. Nonneoplastic Lesions; 2. Neoplastic Lesions
A. Tumors of the Anterior Pituitary Glandb. Other Pituitary Tumors; 3. Discussion; E. Pancreas; 1. Nonneoplastic Lesions; a. Atrophy; 2. Neoplastic Lesions; a. Islet Cell Tumors; b. Exocrine Cell Tumors; 3. Discussion; F. Liver; 1. Nonneoplastic Lesions; a. Foci and Areas of Cellular Alterations; b. Bilary Cysts; c. Miscellaneous Nonneoplastic Lesions; 2. Neoplastic Lesions; a. Neoplastic Nodules; b. Hepatocellular Carcinoma; c. Malignant Hemangioendothelioma; 3. Discussion; G. Alimentary Tract and Abdominal Cavity; 1. Nonneoplastic Lesions; a. Gastric Ulcers
B. Miscellaneous Nonneoplastic Lesions2. Neoplastic Lesions; a. Head, Neck, and Mouth; b. Stomach; c. Intestine; d. Abdominal Cavity; 3. Discussion; H. Salivary Gland; 1. Nonneoplastic Lesions; 2. Neoplastic Lesions; 3. Discussion; I. Cardiovascular System; 1. Nonneoplastic Lesions; a. Myocardial Degeneration and Fibrosis of the Ventricular Wall; b. Cartilaginous and Osseous Metaplasia; c. Cartilaginous Focus at the Base of the Aorta; d. Heart Valves; e. Endocardial Disease; f. Lesions of the Atrium and Auricle; g. Periarteritis Nodosa; h. Incidental Vascular Lesions; 2. Neoplastic Lesions
