Front Matter; Introduction; Bacterial Cell-to-cell Communication (Quorum Sensing); Detection In Vitro of Quorum-Sensing Molecules and Their Inhibitors; Quorum-Sensing Inhibitory Compounds; Mathematical Modeling of Quorum-Sensing Control in Biofilms; Animal Models Commonly Used to Study Quorum-Sensing Inhibitors; In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs; Quorum Sensing in Streptococci; Ironing Out the Biofilm Problem:The Role of Iron in Biofilm Formation; Clinical Wound Healing Using Signal Inhibitors; Back Matter
Summary
"The medical miracle of antibiotics is being eroded by the emergence and spread of bacterial drug resistance. This is compounded by the fact that bacterial bio-films are believed to be a common cause of persistent infections, where growing in a biofilm, bacteria are protected from the host's immune response and antibiotics. This book describes the molecular mechanisms of bacterial cell-to-cell communication (quorum sensing), the development of anti-biofilm inhibitors, and the use of such inhibitors to prevent and treat biofilm-associated bacterial infections in animals and humans."--Jacket
