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Title Pharmacotherapy of pulmonary hypertension / Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch, editors
Published Heidelberg : Springer, 2013


Description 1 online resource (ix, 576 pages) : illustrations (some color)
Series Handbook of experimental pharmacology, 0171-2004 ; volume 218
Handbook of experimental pharmacology ; v. 218.
Contents Part I: Pulmonary Hypertension: Conceptual Bases of the Disease. Definition and Classification of Pulmonary Hypertension / Marc Humbert [and others] -- Pulmonary Hypertension: Pathophysiology and Signaling Pathways / Bradley A. Maron and Joseph Loscalzo -- Pulmonary Hypertension: Pathology / Peter Dorfmüller -- Pulmonary Hypertension: Biomarkers / Christopher J. Rhodes, John Wharton and Martin R. Wilkins -- Rodent Models of Group 1 Pulmonary Hypertension / John J. Ryan, Glenn Marsboom and Stephen L. Archer -- Part II: Pulmonary Hypertension: Established Therapies. General Supportive Care / Ioana R. Preston -- Calcium-Channel Blockers in Pulmonary Arterial Hypertension / Marie-Camille Chaumais, Elise Artaud Macari and Olivier Sitbon -- Prostacyclins / Horst Olschewski -- Endothelin Receptor Antagonists / Martine Clozel, Alessandro Maresta and Marc Humbert -- Phosphodiesterase-5 Inhibitors / Barbara A. Cockrill and Aaron B. Waxman -- Inhaled Nitric Oxide for the Treatment of Pulmonary Arterial Hypertension / Steven H. Abman -- Part III: Pulmonary Hypertension: Novel Pathways and Emerging Therapies. Soluble Guanylate Cyclase Stimulators in Pulmonary Hypertension / Johannes-Peter Stasch and Oleg V. Evgenov -- Therapeutics Targeting of Dysregulated Redox Equilibrium and Endothelial Dysfunction / Michael G. Risbano and Mark T. Gladwin -- Rho-Kinase Inhibitors / Yoshihiro Fukumoto and Hiroaki Shimokawa -- Serotonin Transporter and Serotonin Receptors / Serge Adnot [and others] -- Targeting of Platelet-Derived Growth Factor Signaling in Pulmonary Arterial Hypertension / Eva Berghausen, Henrik ten Freyhaus and Stephan Rosenkranz -- Emerging Molecular Targets for Anti-proliferative Strategies in Pulmonary Arterial Hypertension / Ly Tu and Christophe Guignabert -- Anti-inflammatory and Immunosuppressive Agents in PAH / Jolyane Meloche [and others] -- Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application / Reshma S. Baliga, Raymond J. MacAllister and Adrian J. Hobbs -- Pulmonary Hypertension: Novel Pathways and Emerging Therapies Inhibitors of cGMP and cAMP Metabolism / Yassine Sassi and Jean-Sébastien Hulot -- Pulmonary Hypertension: Old Targets Revisited (Statins, PPARs, Beta-Blockers) / Geoffrey Watson [and others] -- Part IV: Conclusions and Outlook -- Pulmonary Hypertension: Current Management and Future Directions / Lewis J. Rubin
Summary Over the past decade, major advancements in the understanding of the molecular mechanisms and pathophysiology of pulmonary hypertension occurred in parallel with the discovery and development of new therapies. Pharmacological agents that modulate the main pathophysiological pathways of pulmonary arterial hypertension have changed the course of this devastating disease by relieving symptoms and improving and prolonging patients' lives. The first part of the book covers definition, classification, pathophysiology, pathology, biomarkers and animal models of pulmonary hypertension, thus laying the
Notes Includes index
Bibliography Includes bibliographical references and index
Notes English
Online resource; title from PDF title page (SpringerLink, viewed October 7, 2013)
In Springer e-books
Subject Pulmonary hypertension -- Chemotherapy
Pulmonary pharmacology.
Hypertension, Pulmonary -- drug therapy
MEDICAL -- Pharmacology.
Pulmonary pharmacology.
Form Electronic book
Author Humbert, Marc, 1963- editor.
Evgenov, Oleg V., editor
Stasch, Johannes-Peter, editor
ISBN 9783642386640