| Description |
1 online resource (x, 345 pages) : illustrations (some color) |
| Contents |
Intro; Preface; Contents; Contributors; 1: Neuroimaging: Diagnostic Boundaries and Biomarkers; 1.1 Introduction; 1.2 Biomarkers: Definition and Application in Psychiatry; 1.2.1 Definition; 1.2.2 Neuroimaging Biomarkers; 1.2.2.1 Steps for Neuroimaging Biomarker Discovery; 1.3 Primary Psychotic Disorders and Neuroimaging Findings: Which Biomarkers for Psychotic Disorders?; 1.3.1 Diagnostic Biomarkers; 1.3.1.1 Structural Gray and White Matter MRI Findings; 1.3.1.2 Diffusion Tensor Imaging Findings; 1.3.1.3 Functional Neuroimaging Findings; 1.3.1.4 Other Neuroimaging Findings |
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1.3.2 Biomarkers of Schizophrenia Subtypes: Deficit and Non-deficit Schizophrenia1.3.2.1 Structural and Functional Neuroimaging Findings; 1.3.3 Prognostic and Predictive Biomarkers; 1.3.3.1 Prediction of Treatment Response; 1.3.3.2 Prediction of the Transition to Psychosis; 1.4 Machine Learning; 1.4.1 Machine Learning and Generation of Future Instances and Previsions; 1.4.1.1 Main Learning Schemes: Unsupervised and Supervised Machine-Learning Methods; 1.4.2 Applicability of Machine-Learning Techniques in Psychotic Disorders |
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1.4.2.1 Machine-Learning Classifiers and the Prediction of Schizophrenia-Distinctive Patterns and Illness Course1.4.2.2 Neuroimaging Biomarkers for Psychosis Differential Diagnosis; 1.4.2.3 Machine-Learning Algorithms in the Identification of Individuals at High Risk of Psychosis; 1.5 Limits and Future Perspectives of Neuroimaging Biomarkers in Psychotic Disorders; 1.5.1 Limits of Neuroimaging Biomarkers in Psychiatry; 1.5.2 Future Perspectives; 1.6 Conclusions; References; 2: Neuroimaging and Psychopathological Domains; 2.1 Introduction |
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2.2 Brain Imaging and the Three-Syndrome Model of Psychosis2.2.1 Negative Dimension or Psychomotor Poverty; 2.2.1.1 Brain Imaging Findings Relevant to the Negative Dimension or Psychomotor Poverty; 2.2.1.2 Brain Imaging Findings and the Avolition-Apathy Domain; 2.2.1.3 Brain Imaging Findings and the Expressive Deficit Domain; 2.2.2 Disorganization; 2.2.2.1 Brain Imaging Findings and Disorganization; 2.2.2.2 Brain Imaging Findings and Formal Thought Disorder; 2.2.2.3 Structural Cerebral Changes in Relation to FTD; 2.2.2.4 Functional Correlates of FTD |
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2.3 Reality Distortion or Positive Dimension2.3.1 Reality Distortion and Brain Imaging; 2.3.2 Hallucinations and Brain Imaging; 2.3.2.1 Hallucinations and Functional Magnetic Resonance Imaging (fMRI); 2.3.2.2 Symptom-Catching Studies; 2.3.2.3 MRI and Task-Related Brain Activity in Relation to Hallucinations; 2.3.2.4 Resting State MR Studies; 2.3.2.5 Functional Studies Using Radioactive-Tagged Substances (PET/SPECT); 2.3.2.6 Studies of Cerebral Metabolism Using MRI (Magnetic Resonance Spectrography Imaging) |
| Summary |
This book presents the state of the art in the use of neuroimaging technologies in the study of schizophrenia and other primary psychotic disorders. The contributions of neuroimaging in the characterization of these disorders are reviewed across diagnoses, by focusing on psychopathological domains and at-risk populations in order to understand the implications for treatment. The principal neuroimaging findings are described in detail, identifying those that are common to and specific for each disorder and highlighting important pitfalls. Attention is drawn to potential translational aspects of research in the field, with discussion of emerging innovative perspectives. Neuroimaging research has shown that abnormalities of brain structure and function associated with psychiatric disorders do not reflect the boundaries of current diagnostic categories. However, neuroimaging findings are being reconsidered in the light of recent research proposals aimed at re-conceptualizing classification systems in Psychiatry. Written by leading experts, this book will appeal to all with an interest in the field, including researchers, clinicians, and trainees |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed February 8, 2019) |
| Subject |
Psychoses -- Imaging
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Brain -- Imaging
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Brain -- Imaging
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| Form |
Electronic book
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| Author |
Galderisi, Silvana, editor
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DeLisi, Lynn E., editor
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Borgwardt, Stefan, editor
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| ISBN |
9783319973074 |
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331997307X |
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3319973061 |
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9783319973067 |
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9783319973081 |
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3319973088 |
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