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Title Psychiatric genetics : methods and reviews / edited by Marion Leboyer and Frank Bellivier
Published Totowa, N.J. : Humana Press, ©2003


Description 1 online resource (ix, 268 pages) : illustrations
Series Methods in molecular medicine ; 77
Methods in molecular medicine ; 77. 1543-1894
Contents Psychiatric genetics. Overview on achievements, problems, perspectives / W. Maier -- Analytical methods applied to psychiatric genetics / E.L. Grigorenko and D.L. Pauls -- Genetic markers in psychiatric genetics / T. Bourgeron and B. Giros -- Clinical assessment in psychiatric genetics / P. Gorwood -- Genetic association studies. Definition of cases and controls / F. Bellivier -- Searching for alternative phenotypes in psychiatric genetics / M. Leboyer -- Intermediate cognitive phenotypes associated with schizophrenia / M.F. Egan and T.E. Goldberg -- Biochemical endophenotypes in personality disorders / A.S. New and L.J. Siever -- Electrophysiological phenotypes / R. Freedman -- Brain imaging as an approach to phenotype characterization for genetic studies of schizophrenia / J.H. Callicott and D.R. Weinberger -- Psychiatric genetics. Future and prospects / M.T. Tsuang, L. Taylor and S.V. Faraone
Summary Enthusiasm about the role that genetics plays in our understanding of behavioral phenotypes has led to the development of many new epidemiological and statistical strategies, as well as to refinements in phenotype analysis. In Psychiatric Genetics: Methods and Reviews, hands-on experts comprehensively review the tools and methods currently available to uncover the genetic basis of psychiatric disorders, and then demonstrate through archetypical examples how these strategies can be used. Casting their net widely, the authors critically examine the key methodological issues involved in phenotypic analysis-including study design, molecular techniques, clinical interviews, and population sampling methods-and discuss new and alternate strategies that identify candidate symptoms and endophenotypes with better genetic validity. These strategies suggest cognitive intermediate phenotypes in schizophrenia, show how personality disorders may generate biologically mediated traits in the full-blown disorders, and yield data about P50 and P300 as endophenotypes in schizophrenia and alcoholism. One of the most promising approaches for the identification of valid phenotypes-the union of neuropsychological experimental designs and in vivo physiological brain mapping-is also discussed. Practical and timely, Psychiatric Genetics: Methods and Reviews lays the cornerstone for the new diagnostics in psychiatric genetics-the unraveling of the genetic basis of psychiatric disorders and the development of new therapies through the precise identification of the phenotypes involved
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
Print version record
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
In Springer Protocols
Subject Mental illness -- Genetic aspects.
Behavior genetics
Psychophysiology -- Genetic aspects.
Genetics -- Technique.
Mental Disorders -- genetics
Genetics, Behavioral
Epidemiologic Research Design
Genetic Techniques
Mental Disorders -- epidemiology
MEDICAL -- Psychiatry -- General.
PSYCHOLOGY -- Psychopathology -- General.
PSYCHOLOGY -- Clinical Psychology.
PSYCHOLOGY -- Mental Illness.
MEDICAL -- Mental Health.
Genetics -- Technique
Behavior genetics
Mental illness -- Genetic aspects
Psychophysiology -- Genetic aspects
Psychische stoornissen.
Wetenschappelijke technieken.
Genre/Form Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Leboyer, Marion.
Bellivier, Frank.
ISBN 1592593488