Preparation and utilization of microarrays -- Comparative studies using cDNA vs oligonucleotide arrays -- Quality control of expression profiling data -- An introduction to cluster analysis -- Transcription profiling in toxicology -- Microarrays in drug metabolism and toxicology: rat liver responses to prototypical CYP inducers -- Characterization of hepatocytes and their use as a model system in toxicogenomics -- Molecular signatures of dioxin toxicity -- Toxicogenomic dissection of the antioxidant response -- An overview of mechanistic toxicogenomic studies -- Gene expression and profile databases in toxicity testing -- Predictive toxicogenomics -- Unsupervised hierarchical clustering of toxicants -- Toxicogenomic analysis in clincal pharmacogenomic studies -- The future of toxicogenomics
Summary
Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new subdiscipline. With a focus on toxicology, it introduces the overall concept underlying microarray/oligonucleotide array-based genomic analysis and how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. An important feature is the book's focus on the basics of data analysis and clustering methods, suc
