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Title Intramembrane-cleaving proteases (I-CLiPs) / edited by Nigel M. Hooper and Uwe Lendeckel
Published Dordrect, Netherlands : Springer, ©2007


Description 1 online resource (ix, 142 pages) : illustrations
Series Proteases in biology and disease ; v. 6
Proteases in biology and disease ; v. 6.
Contents Site-2 protease at ten -- Signal peptide peptidases -- GXGD-type intramembrane proteases -- Rhomboid intramembrane serine proteases -- Proteases of the Rhomboid family in the yeast Saccharomyces Cerevisiae -- [gamma]-Secretase and alzheimer's disease -- [gamma]-Secretase mediated proteolysis: at the cutting edge of notch signaling
Summary In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called 'intramembrane-cleaving proteases' (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer's and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs
Analysis celbiologie
cellular biology
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer e-books
Subject Endopeptidases -- Metabolism
Proteolytic enzymes -- Metabolism
Alzheimer's disease.
Notch proteins.
Saccharomyces cerevisiae.
Cell Membrane -- enzymology
Endopeptidases -- metabolism
Peptide Hydrolases -- metabolism
Alzheimer Disease
Receptors, Notch
Saccharomyces cerevisiae
Serine Proteases
MEDICAL -- Immunology.
Proteolytic enzymes -- Metabolism.
Endopeptidases -- metabolism.
Peptide Hydrolases -- metabolism.
Cell membrane -- Enzymology.
Sciences de la vie.
Alzheimer's disease
Notch proteins
Saccharomyces cerevisiae
Form Electronic book
Author Hooper, N. M.
Lendeckel, Uwe.
ISBN 9781402063114