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E-book

Title Disruption of protein-protein interfaces : in search of new inhibitors / Stefano Mangani, editor
Published Berlin ; New York : Springer, ©2013

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Description 1 online resource
Contents Drug discovery by targeting protein-protein interactions -- Protein-Protein Interaction Inhibitors: case studies on small molecules and natural compounds -- Disrupting Protein-Protein Interfaces using GRID Molecular Interaction Fields -- NMR as a tool to target protein-protein interactions -- Protein-protein interactions in the solid state The troubles of crystallizing of protein- protein complexes -- Fluorescence observables and enzyme kinetics in the investigation of PPI modulation by small molecules Detection, mechanistic insight, functional consequences
Summary "Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces
Analysis Chemistry
Chemistry, Organic
Organic Chemistry
chemie
organische scheikunde
Chemistry (General)
Chemie (algemeen)
Notes Includes index
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed July 12, 2013)
Subject Protein-protein interactions.
Protein Binding -- drug effects
Drug Discovery
Proteins -- antagonists & inhibitors
SCIENCE -- Life Sciences -- Biochemistry.
Chimie.
Science des matériaux.
Protein-protein interactions
Form Electronic book
Author Mangani, Stefano
ISBN 9783642379994
3642379990
3642379982
9783642379987