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Title Advances in protein chemistry. Volume 52, Cytokines / edited by James A. Wells
Published San Diego ; London : Academic Press, ©1999


Description 1 online resource : illustrations
Series Advances in protein chemistry ; v. 52
Advances in protein chemistry ; v. 52.
Contents Front Cover; Advances in Protein Chemistry, Volume 52; Copyright Page; Contents; Preface; Chapter 1. General Classes and Functions of Four-Helix Bundle Cytokines; I. Overview; II. Long-Chain Cytokines Using Homodimeric Type I Cytokine Receptors for Signaling; III. Short-Chain Cytokines Using Homodimeric Tyrosine Kinase Receptors for Signaling: Macrophage Colony-Stimulating Factor, Stem Cell Factor, and FLK2/FLT3 Ligand
IV. Long-Chain Cytokines Using Leukemia Inhibitory Factor Receptors and/or gp130 for Signaling: Pleiotropic Cytokines: Interleukin-6, Interleukin-11, Leukemia Inhibitory Factor, Oncostatin M, Ciliary Neurotrophic Factor, and Cardiotrophin-1V. Short-Chain Cytokines Using ßc for Signaling: Hemopoietic Cytokines: Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3, and Interleukin-5; VI. Cytokines Using Class II Cytokine Receptors for Signaling: Viral Resistance Cytokines: Interferons, Interleukin-10, and Interleukin-12
VII. Short-Chain Cytokines Using ?c or Interleukin-4 Receptor for Signaling: Acquired Immunity Cytokines: Interleukins-2, -4, -7, -9, -13, and -15VIII. Concluding Comments; References; Chapter 2. Structural Basis for Cytokine Hormone-Receptor Recognition and Receptor Activation; I. Introduction; II. Class 1 of the Superfamily; III. Class 2 of the Superfamily; IV. Comparison of Class 1 and Class 2 Receptors; References; Chapter 3. General Mechanisms of Cytokine Receptor Signaling; I. Introduction
II. Multicomponent Receptors for the Interleukin 6/Ciliary Neurotrophic Factor Cytokine Family: Shared Signal Transducing Receptor ComponentsIII. Cytokine Binding Drives Receptor Complex Assembly; IV. Homo- or Heterodimerization of Signal Transducing Components is Required for Signaling: JAK Kinases are Preassociated with Signal Transducers; V. Shared Principles of Receptor Activation by Different Cytokine Families and Receptor Tyrosine Kinases; VI. STATs and Other Substrates Activated by Cytokine Receptors
VII. Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine ReceptorsVIII. Phosphatases and Other Regulators of Cytokine Receptor Signaling; IX. Therapeutic Approaches for Modulating Cytokine Signaling; References; Chapter 4. Cytokines in Hematopoiesis: Specificity and Redundancy in Receptor Function; I. Introduction; II. Structure and Regulation of Hematopoietic Compartment; III. Historical Perspective; IV. Experimental Models to Study Cytokine Receptors; V. Inductive versus Stochastic Models of Hematopoiesis; VI. Cytokine Receptor Signaling
Summary Our most complete understanding of hormone receptor signaling may be exemplified in a family of hormones and receptors known as the cytokine superfamily. This volume is devoted to describing members of this hormone/receptor family from their molecular structures to their physiological effects. These hormones are not only biologically fascinating, but are also tremendously useful medicines.The first three chapters review the basic events in binding and signaling. The remaining papers present the cellular biology and physiological processes controlled by these hormones and receptors
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Proteins -- Denaturation.
Protein Denaturation
MEDICAL -- Biochemistry.
Proteins -- Denaturation.
Form Electronic book
Author Wells, James A
ISBN 9780120342525
Other Titles Cytokines