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Book Cover
E-book

Title Molecular modeling of proteins / Andreas Kukol, editor
Edition Second edition
Published New York : Humana Press, [2015]
©2015

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Description 1 online resource (x, 474 pages) : illustrations
Series Methods in molecular biology, 1940-6029 ; v. 1215
Methods in molecular biology (Clifton, N.J.) ; volume 1215. 1064-3745
Contents Molecular Dynamics Simulations -- Transition Path Sampling with Quantum/Classical Mechanics for Reaction Rates -- Current Status of Protein Force Fields for Molecular Dynamics Simulations -- Lipid Membranes for Membrane Proteins -- Molecular Dynamics Simulations of Membrane Proteins -- Membrane-Associated Proteins and Peptides -- Coarse-Grained Force Fields for Molecular Simulations -- Tackling Sampling Challenges in Biomolecular Simulations -- Calculation of Binding Free Energies -- The Use of Experimental Structures to Model Protein Dynamics -- Computing Ensembles of Transitions with Molecular Dynamics Simulations -- Accelerated Molecular Dynamics and Protein Conformational Change: A Theoretical and Practical Guide Using a Membrane Embedded Model Neurotransmitter Transporter -- Simulations and Experiments in Protein Folding -- Comparative Modeling of Proteins -- De Novo Membrane Protein Structure Prediction -- NMR-Based Modeling and Refinement of Protein 3D Structures -- Methods for Predicting Protein Ligand Binding Sites -- Information-Driven Structural Modelling of Protein-Protein Interactions -- Identifying Putative Drug Targets and Potential Drug Leads: Starting Points for Virtual Screening and Docking -- Molecular Docking to Flexible Targets
Summary Molecular Modeling of Proteins, Second Edition provides a theoretical background of various methods available and enables non-specialists to apply methods to their problems by including updated chapters and new material not covered in the first edition. This detailed volume opens by featuring classical and advanced simulation methods as well as methods to set-up complex systems such as lipid membranes and membrane proteins, and continues with chapters devoted to the simulation and analysis of conformational changes of proteins, computational methods for protein structure prediction, usage of experimental data in combination with computational techniques, as well as protein-ligand interactions, which are relevant in the drug design process. Written for the highly successful Methods in Molecular Biology series, chapters include thorough introductions, step-by-step instructions, and notes on troubleshooting and avoiding common pitfalls. Update-to-date and authoritative, Molecular Modeling of Proteins, Second Edition aims to aid researchers in the physical, chemical, and biosciences interested in utilizing this powerful technology
Analysis eiwitten
proteins
modelleren
modeling
computertechnieken
computer techniques
Proteins and Enzymes
Eiwitten en enzymen
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (SpringerLink, viewed October 30, 2014)
Subject Proteins -- Structure -- Computer simulation
Computer simulation.
Digital computer simulation.
Carrier proteins.
Proteins -- Conformation.
Proteins -- chemistry
Computer Simulation
Models, Molecular
Carrier Proteins
Protein Conformation
simulation.
Biology, life sciences.
Proteins.
Science -- Life Sciences -- General.
Science -- Life Sciences -- Biochemistry.
Proteins -- Conformation
Digital computer simulation
Computer simulation
Carrier proteins
Proteins -- Structure -- Computer simulation
Modèle moléculaire.
Simulation ordinateur.
Eiwitten.
Wetenschappelijke technieken.
NMR.
Computersimulaties.
Protéines.
Genre/Form Laboratory manuals.
Manuels de laboratoire.
Form Electronic book
Author Kukol, Andreas, editor
LC no. 2014945209
ISBN 9781493914654
1493914650