| Description |
1 online resource |
| Series |
NATO Science for Peace and Security Series A: Chemistry and Biology |
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NATO science for peace and security series. Series A, Chemistry and biology.
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| Contents |
880-01 Note continued: 13. Protein Function Prediction From Structure in Structural Genomics and Its Contribution to the Study of Health and Disease / Janet M. Thornton / James D. Watson -- 14. Crystal Structures of the [beta][subscript 2]-Adrenergic Receptor / Tong Sun Kobilka / Foon Sun Thian / Hee-Jung Choi / Soren G.F. Rasmussen / Daniel M. Rosenbaum / William I. Weis / Asna Masood / Xiao-Jie Yao / Peter W. Day / Charles Parnot / Juan J. Fung / Venkata R.P. Ratnala / Brian K. Kobilka / Vadim Cherezov / Michael A. Hanson / Peter Kuhn / Raymond C. Stevens / Patricia C. Edwards / Gebhard F.X. Schertler / Manfred Burghammer / Ruslan Sanishvili / Robert F. Fischetti / Daniel K. Rohrer |
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880-01/(S Surface proteins of gram-positive pathogens: using crystallography to uncover novel features in drug and vaccine candidates / Edward N. Baker, Thomas Proft and Haejoo Kang -- The rapid crystallization strategy for structure-based inhibitor design / Terese Bergfors -- Fragment-based drug discovery in academia: experiences from a tuberculosis programme / Timo J. Heikkila [and others] -- Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukemia / Sandra W. Cowan-Jacob [and others] -- Integrating crystallography into early metabolism studies / Gabriele Cruciani [and others] -- The foundations of protein-ligand interaction / Gerhard Klebe -- Structure-based design of trna-guanine transglycosylase inhibitors / Gerhard Klebe -- Progress on new hepatitis c virus targets: NS2 and NS5A / Joseph Marcotrigiano -- Protein structure modeling / Narayanan Eswar and Andrej Sali -- Structural biology and molecular modeling in the design of novel dpp-4 inhibitors / Giovanna Scapin -- Tools to make 3D structural data more comprehensible: emovie & proteopedia / Eran Hodis, Jaime Prilusky and Joel L. Sussman -- Structural studies on acetylcholinesterase and paraoxonase directed towards development of therapeutic biomolecules for the treatment of degenerative diseases and protection against chemical threat agents / Joel L. Sussman and Israel Silman -- Protein function prediction from structure in structural genomics and its contribution to the study of health and disease / James D. Watson and Janet M. Thornton -- Crystal structures of the β2-adrenergic receptor / William I. Weis [and others] -- Can structures lead to better drugsLessons from ribosome research / Ada Yonath |
| Summary |
The synergism played by crystallography and drug discovery is the central focus of this volume which comprises papers presented at the 40th Erice Course held from 28 May to 8 June 2008. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future |
| Bibliography |
Includes bibliographical references |
| Notes |
English |
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Print version record |
| Subject |
Macromolecules -- Structure -- Congresses
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Proteins -- Biotechnology -- Congresses
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Crystallography -- Congresses
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Drug development -- Congresses
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Proteins -- Biotechnology.
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Crystallography.
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Drug development.
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Macromolecules -- Structure.
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Physique.
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Crystallography.
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Drug development.
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Macromolecules -- Structure.
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Proteins -- Biotechnology.
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| Genre/Form |
Conference papers and proceedings.
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Conference papers and proceedings.
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Actes de congrès.
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| Form |
Electronic book
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| Author |
Sussman, Joel.
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Spadon, Paola.
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NATO Advanced Study Institute "From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism" (2008 : Erice, Italy)
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| ISBN |
9789048123391 |
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9048123399 |
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9789048123384 |
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9048123380 |
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9048123372 |
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9789048123377 |
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