|
Protein unfolding
|
--subdivision Denaturation under individual proteins and groups of proteins, e.g. Insulin--Denaturation
|
|
Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions
|
|
The ability of a protein to retain its structural conformation or its activity when subjected to physical or chemical manipulations
|
|
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS
|
|
Add Marked to Bag
Add All On Page
|