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Book Cover

Title Protein-protein complexes : analysis, modeling and drug design / edited by Martin Zacharias
Published London : Imperial College Press ; Singapore ; Hackensack, NJ : Distributed by World Scientific Pub. Co., ©2010


Description 1 online resource (ix, 390 pages) : illustrations (some color)
Contents X-ray study of protein-protein complexes and analysis of interfaces / Joel Janin -- A structural perspective on protein-protein interactions in macromolecular assemblies / Ranjit P. Bahadur -- Energetics of protein-protein interactions / Ilian Jelesarov -- Kinetics of biomacromolecular complex formation: theory and experiment / Georgi V. Pachov, Razif R. Gabdoulline and Rebecca C. Wade -- Evolutionary trace of protein functional determinants / Olivier Lichtarge -- Protein-protein docking / Adrien Saladin and Chantal Prevost -- Data-driven docking: using external information to spark the biomolecular rendez-vous / Adrien S.J. Melquiond and Alexandre M.J.J. Bonvin -- High-resolution protein-protein docking / Nir London and Ora Schueler-Furman -- Scoring and refinement of predicted protein-protein complexes / Martin Zacharias -- Motif-mediated protein interactions and their role in disease / Holger Dinkel and Heinrich Sticht -- Prediction and calculation of protein-protein binding affinities and mutation effects / Sébastien Fiorucci, Serge Antonczak and Jérôme Golebiowski -- Small-molecule inhibitors of protein-protein interactions / Thorsten Berg -- Protein dynamics and drug design: the role of molecular simulations / Giulia Morra, Alessandro Genoni and Giorgio Colombo
Summary Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Protein-protein interactions.
Carrier proteins.
Proteins -- Conformation.
Multiprotein Complexes -- chemistry
Protein Interaction Mapping
Carrier Proteins
Protein Conformation
SCIENCE -- Life Sciences -- Biochemistry.
Proteins -- Conformation
Carrier proteins
Protein-protein interactions
Form Electronic book
Author Zacharias, Martin
LC no. 2010484189
ISBN 9781848163409