Front Cover; Inside Cover; Contents; Chapter 1 Proteasomes: A Historical Retrospective; Chapter 2 Proteasomes in Prokaryotes; Chapter 3 Proteasome Crystal Structures; Chapter 4 Subunit Arrangement in the Human Proteasome; Chapter 5. Active Sites and Assembly of the 20S Proteasome; Chapter 6 The Regulatory Particle of the Yeast Proteasome; Chapter 7 The Mammalian Regulatory Complex of the 26 S Proteasome; Chapter 8 The 20S Proteasome Activator PA28 or 11S Regulator; Chapter 9 Proteasome Activators and Synthetic Modulators:; Chapter 10The Proteasome Inhibitors and Their Uses
Chapter 11 Intracellular Localization of ProteasomesChapter 12 Primary Destruction Signals; Chapter 13 The Ubiquitin System in Yeast; Chapter 14. The Ubiquitin-Proteasome Pathway in Mammals: Mechanisms of Action and Involvement in Pathogenesis of Human Diseases; Chapter 15. Deubiquitinating Enzymes and the Regulation of Proteolysis; Chapter 16 Degradation of Ornithine Decarboxylase, a Ubiquitin-Independent Proteasomal Process; Chap
Summary
This book highlights proteasome structures and how they are related to different aspects of proteasome function. Moreover, the book reports on the functional roles these highly developed proteolytic machines play within the cell. It was a great surprise to the scientific world that proteolysis provides crucial functions in cellular regulation
