| Description |
1 online resource |
| Series |
Molecular pathology library |
|
Molecular pathology library series.
|
| Contents |
Intro; Contents; Editors and Contributors; Part I: General Principles; Chapter 1: Precision Medicine in Prostate Cancer: Approach to the Patient; Introduction; Precision Medicine in Prostate Cancer; Newly Diagnosed Prostate Cancer; Advanced Prostate Cancer; Initial Clinical Encounter; Family History in Prostate Disease; Informed Consent; Patient Preferences and Data Privacy; Actionability of Precision Medicine Results; Turnaround Time; Tissue for Genomic Profiling and Need for Serial Biopsies; Understanding â#x80;#x9C;Precision Medicine Reportsâ#x80;#x9D |
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Communicating Genomic Information to Clinicians and PatientsUnique Issues Related to Incidental Discovery of Germline Mutations; Future Direction; Resources for Patients and Clinicians; References; Chapter 2: Epidemiology and Etiology; Introduction: Incidence and Mortality; Etiology and Risk Factors; Modifiable; Age; Family History and Genetic Alterations (Inherited and Acquired); Race and Ethnicity; Modifiable; Obesity, Exercise, Diet, and Diabetes (Metabolic); Smoking; Conclusions; References; Chapter 3: High-Grade Prostatic Intraepithelial Neoplasia |
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Definition, Incidence and Evidence of Preneoplastic ProcessMolecular Features of HGPIN; Telomere Shortening; Cytogenetic Alterations; Overexpression of p16; c-myc Amplification and Caveolin-1 Overexpression; Dysregulation of Annexin; Glutathione-S-Transferase Gene Methylation; Mammalian Target of Rapamycin (mTOR) Pathway; MicroRNA Expression Profiles; TMPRSS2-ERG Fusion; Clinical Significance of HGPIN; References; Chapter 4: Pathology of Prostate Cancer; Introduction; Diagnosis of Prostatic Adenocarcinoma; Abnormal Architecture or Pattern of Glands; Loss of Basal Cell Layer |
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Nuclear AtypiaMinor Criteria That Are Helpfulâ#x80;#x94;But Not Requiredâ#x80;#x94;In the Diagnosis of Prostatic Adenocarcinoma; Intraluminal Blue-Tinged Mucin; Amorphous Pink Secretions; Crystalloids; Cytoplasmic Changes; Grading of Prostatic Adenocarcinoma; Variants of Acinar Adenocarcinoma; Variants of Non-acinar Carcinoma; Immunohistochemistry; Treatment Effect; Special Issues Related to Biopsy, TURP, and Prostatectomy Specimens; Needle Core Biopsy; Transurethral Resection of Prostate (TURP); Radical Prostatectomy; Conclusion; References; Chapter 5: Genetic Susceptibility; Introduction |
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Hereditary Prostate CancerBRCA1 and BRCA2 Genes; BRCA Genes and Cancer Risk; BRCA and Tumourigenesis; Poly(ADP-ribose) Polymerase 1 (PARP1); Susceptibility Genes; Androgen Receptor (AR) Gene; RNASEL Gene; TMPRSS2-ERG Gene Fusion; HOXB13; Mismatch Repair (MMR) Genes and Prostate Cancer; Lynch Syndrome; MSH2; Fanconi Anaemia; The FA Pathway; FA Genes and Prostate Cancer; DNA Adducts; Conclusion; References; Chapter 6: Racial Differences; Differences in the Epidemiology of Prostate Cancer Among Ethnicities; Incidence and Mortality Across Ethnic Populations Within the United States |
| Summary |
This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community |
| Notes |
Includes index |
| Subject |
Prostate -- Cancer -- Molecular diagnosis
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Precision medicine.
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Prostatic Neoplasms -- pathology
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Precision Medicine
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Prostatic Neoplasms -- genetics
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Oncology.
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Urology & urogenital medicine.
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Pathology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Prostate -- Cancer -- Molecular diagnosis
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| Form |
Electronic book
|
| Author |
Robinson, Brian D., editor
|
|
Mosquera, Juan Miguel, editor
|
|
Ro, Jae Y., editor.
|
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Divatia, Mukul, editor
|
| ISBN |
9783319640969 |
|
3319640968 |
|
