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Title Prolactin disorders : from basic science to clinical management / Nicholas A. Tritos, Anne Klibanski, editors
Published Cham : Humana Press, [2019]


Description 1 online resource (249 pages)
Series Contemporary Endocrinology
Contemporary endocrinology (Totowa, N.J.)
Contents Intro; Series Editor Foreword; Preface; Contents; Contributors; Chapter 1: History of Prolactin Disorders; Medical Therapy; Introduction; Did Mary Tudor of England Have a Prolactinoma? [1]; The Discovery of Human Prolactin; Cell of Origin; Prolactin Action; Neuroendocrine Regulation; Actions of High Levels of Prolactin; Medical Treatment of Hyperprolactinaemia; Pituitary Tumour Shrinkage; Surgery; Radiotherapy; Summary; References; Chapter 2: Pituitary Anatomy and Development; Historical Anatomy; Macroscopic Anatomy; Landmarks of the Sellar Region; Pituitary Gland
Vascularization of the Pituitary GlandEmbryologic Anatomy; Radiologic Anatomy; Microscopic and Functional Anatomy; Anterior Pituitary (Adenohypophysis); Pars Distalis; Pars Intermedia; Marginal Zone; Pars Tuberalis; Posterior Pituitary; Concluding Remarks; References; Chapter 3: Prolactin Assays and Regulation of Secretion: Animal and Human Data; Prolactin Assays; What Is Measured in Prolactin Assays?; The History of Prolactin Assays; Measurement of Prolactin Levels; Analytical Pitfalls; The "Hook Effect"; Macroprolactin; Interference from Heterophilic Antibodies; Interference with Biotin
Chapter 4: Physiological Actions and ReceptorsPhysiological Actions in Humans and Other Mammals; Mammary Glands; Reproductive Tissues; Receptors and Signaling; Conclusions; References; Chapter 5: Prolactin Excess and Deficiency: Epidemiology, Causes (Excluding Prolactin-Secreting Pituitary Tumors); Introduction; Normal Levels of Prolactin; Prolactin Excess: Epidemiology and Causes; Physiologic Causes; Pregnancy; Nipple Stimulation and Lactation; Stress; Other; Pathologic Causes; Decreased Dopaminergic Inhibition of Prolactin Secretion; Decreased Clearance of Prolactin
Prolactin Increase Due to Neural MechanismGenetic Causes: Germline Loss-of-Function Mutation; Other Causes; Pharmacological Causes; Antipsychotics; Antidepressants; Gastric Motility Drugs; Antihypertensive Drugs; Estrogens; Opioids; Other Drugs; Idiopathic Hyperprolactinemia; Prolactin Deficiency: Epidemiology and Causes; Pathological Causes; Sheehan's Syndrome; Genetic Causes; Pharmacological; Dopamine Agonists; Aripiprazole; Conclusion; References; Chapter 6: Prolactin-Secreting Pituitary Adenomas: Epidemiology and Natural History; Epidemiology of Sporadic Prolactinomas; Population Studies
Summary This unique book will serve as a valuable resource for clinicians and researchers interested in prolactin physiology and pathophysiology and those who are involved in the care of patients with related disorders, including hyperprolactinemia and prolactin-secreting pituitary adenomas. Timely and up-to-date, it opens with a review of the historical aspects of prolactin research and a discussion of pituitary anatomy and physiology. Several chapters examine basic and translational aspects of prolactin physiology, focusing on recent developments and future directions. The main portion of the book is comprised of chapters presenting the clinical aspects of prolactin excess or deficiency, with particular emphasis placed on prolactin-secreting pituitary adenomas and co-secreting tumors. Concluding chapters address prolactin-secreting pituitary adenomas in special populations - women in the preconception period or during pregnancy, children and adolescents, and men - as well as plurihormonal and aggressive adenomas and carcinomas. Written and edited by experts in the field, Prolactin Disorders will be a ready reference for a diverse array of professionals, from basic scientists to clinical investigators and clinicians from several specialties, including specialists in endocrinology, neurosurgery, radiation oncology and neuro-oncology
Notes Print version record
Subject Prolactin.
Prolactinoma -- therapy
Form Electronic book
Author Tritos, Nicholas A., editor
Klibanski, Anne, editor
ISBN 9783030118365