Title Clinical applications of mifepristone (RU 486) and other antiprogestins : assessing the science and recommending a research agenda / Committee on Antiprogestins: Assessing the Science, Division of Health Promotion and Disease Prevention, Institute of Medicine ; Molla S. Donaldson [and others], editors

Published Washington, D.C. : National Academy Press, 1993

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Description 1 online resource (xi, 288 pages) : illustrations Contents Background and historical perspectives -- IOM report -- Cross-cutting recommendations -- Uses of antiprogestins: the reproductive cycle -- Contraception -- Post-coital contraception -- Menses induction -- Uses of antiprogestins: the reproductive cycle -- Pregnancy termination during the first trimester -- Pregnancy termination during the second trimester -- Cervical ripening -- Labor induction in late pregnancy -- Other therapeutic uses of antiprogestins -- Endometriosis -- Uterine leiomyomas (fibroids) -- Breast cancer -- Meningiomas -- Antiglucocorticoid effects of antiprogestins -- Glucocorticoid function -- Therapeutic use of mifepristone (RU 486) as an antiglucocorticoid -- Adverse antiglucocorticoid effects of antiprogestins -- Animals as models for studying antiprogestins -- Agenda for the IOM workshop "Antiprogestins: Assessing the Science" -- Background papers and presentations (in order of presentation at IOM workshop) -- 1993: RU 486: a decade on today and tomorrow / Etienne-Emile Baulieu (cont) Overview and background: mechanism of action of antiprogestins / Nancy L. Weigel -- Use of antiprogestins in the reproductive cycle / Lynnette Kaye Nieman -- Potential contraceptive effects of antigestogens / David T. Baird -- Use of antiprogestins before 63 days of amenorrhea / Marc Bygdeman -- Uses of antiprogestins after 63 days of amenorrhea / Ancre Ulmann and Louise Silvestre -- Comments on session II -- David Grimes -- Use of antiprogestins in the management of endometriosis and leiomyoma / Samuel S.C. Yen -- Antiprogestins and the treatment of breast cancer / Kathryn B. Horwitz -- Uses of RU 486 as an antiglucocorticoid / Lynnette Kaye Nieman -- Primate models for the study of antiprogestins in reproductive medicine / Gary D. Hodgen -- Antiprogestogens: perspectives from a global research program / P.F.A. Van Look and H. von Hertzen -- Observers at the workshop on antiprogestins Notes "Support for this project was provided by a grant from the Henry J. Kaiser Family Foundation, Menlo Park, California."--Title page verso Committee chairman: Leslie Z. Benet Bibliography Includes bibliographical references and index Notes English Print version record Subject Mifepristone -- Research Abortifacients -- Research Progesterone -- Antagonists -- Research Mifepristone. Abortifacients. Mifepristone Abortifacient Agents Progesterone -- antagonists & inhibitors MEDICAL -- Pharmacology. Abortifacients Mifepristone RU 486 Form Electronic book Author Benet, Leslie Z. Donaldson, Molla S. Institute of Medicine (U.S.). Committee on Antiprogestins: Assessing the Science. Institute of Medicine (U.S.). Division of Health Promotion and Disease Prevention. LC no. 93085360 ISBN 0585024782 9780585024783 1280196025 9781280196027 9786610196029 6610196028 0309598354 9780309598354

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