| Description |
1 online resource |
| Contents |
1. Overview : therapeutic biomarkers in cancer / Sherry X. Yang and Janet E. Dancey -- 2. Statistical considerations in the development and evaluation of therapeutic biomarkers in cancer / Lisa M. McShane, Edward L. Korn, and Boris Freidlin -- 3. Role of biomarkers in clinical development of cancer therapies / Helen X. Chen -- 4. HER-2 as a prognostic and predictive biomarker in cancer / Suparna B. Wedam and Stanley Lipkowitz -- 5. Hormone receptors and endocrine therapy in breast cancer / Sherry X. Yang -- 6. Predictive biomarkers for epidermal growth factor receptor agents in non-small cell lung cancer / John Hilton, Penelope A. Bradbury, and Janet Dancey -- 7. Markers of sensitivity and resistance to EGFR inhibitors in colorectal cancer / Jose G. Monzon and Janet Dancey -- 8. Targeting BCR-ABL for molecular therapy of chronic myelogenous leukemia / Shamudheen Rafiyath, Guoqing Wei, and Delong Liu -- 9. Gastrointestinal stromal tumors : from molecular pathogenesis to therapy / Joaquina Baranda, Rashna Madan, and Andrew K. Godwin -- 10. PML/RARa fusion gene and response to retinoic acid and arsenic trioxide treatment / Alicja M. Gruszka and Myriam Alcalay -- 11. Dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity -- 12. UGT1A1 polymorphisms and mutations lead to irinotecan-induced toxicity / K.M. Reece and W.D. Figg -- 13. The 21-gene recurrence score and benefit of chemotherapy in estrogen receptor-positive breast cancer / Petra Rietschel and Joseph A. Sparano -- 14. Mammaprint for individualized recurrence risk assessment and treatment recommendations for early-stage breast cancer patients / Sonal J. Desai and Tianhong Li -- 15. BRCA mutation and PARP inhibitors / Marcie K. Weil [and others] -- 16. EML4-ALK fusion gene and therapy with ALK-targeted agents in non-small cell lung cancer / Vimal Patel and Biren Saraiya -- 17. BRAF-targeted therapy in metastatic melanoma / Noori Kim and April Deng |
| Summary |
In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarker |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Cancer -- Molecular diagnosis.
|
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Cancer -- Prognosis.
|
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Tumor markers.
|
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Biomarkers, Tumor
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Cancer -- Molecular diagnosis.
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Cancer -- Prognosis.
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Tumor markers.
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| Genre/Form |
Handbooks and manuals.
|
| Form |
Electronic book
|
| ISBN |
1299704484 |
|
9781299704480 |
|
9789814364669 |
|
9814364665 |
|
9789814364652 |
|
9814364657 |
|
0429088450 |
|
9780429088452 |
|
