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Title Progestins and the mammary gland : from basic science to clinical applications / O. Conneely, C. Otto, editors
Published Berlin ; New York : Springer, ©2008


Description 1 online resource (xvii, 197 pages) : illustrations (some color)
Series Ernst Schering Foundation symposium proceedings, 0947-6075 ; 2007/1
Ernst Schering Foundation symposium proceedings ; 2007/1. 0947-6075
Contents Mammary development, carcinomas and progesterone: role of wnt signaling -- Dynamic regulation of progesterone receptor activity in female reproductive tissues -- Progesterone signaling in mammary gland development -- Steroid receptor coactivator 2: an essential coregulator of progestin-induced uterine and mammary morphogenesis -- Progesterone receptor isoforms in normal and malignant breast -- Inhibition of mammary tumorigenesis by estrogen and progesterone in genetically engineered mice -- Estrogens, progestins, and risk of breast cancer -- In vivo characterization of progestins with reduced non-genomic activity in vitro -- In vitro and in vivo characterization of a novel nonsteroidal, species-specific progesterone receptor modulator, PRA-910
Summary "Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21-23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed."--Jacket
Bibliography Includes bibliographical references
Notes Print version record
Subject Progestational hormones -- Congresses
Mammary glands -- Congresses
Mammary glands -- Diseases -- Endocrine aspects -- Congresses
Progestational hormones.
Breast -- Diseases.
Mammary glands.
Breast Diseases
Mammary Glands, Human
SOCIAL SCIENCE -- Anthropology -- Physical.
Mammary glands.
Mammary glands -- Diseases -- Endocrine aspects.
Breast Diseases.
Mammary Glands, Human.
Progestational hormones.
Breast -- Diseases.
Mammary glands.
Progestational hormones.
Genre/Form Conference papers and proceedings.
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Conneely, O.
Otto, C. (Christiane)
ISBN 9783540734932