| Description |
1 online resource (323 pages) : illustrations (some color) |
| Series |
Molecular biology intelligence unit |
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Molecular biology intelligence unit (Unnumbered)
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| Contents |
Machine derived contents note: Preface xvii -- 1. EMT Concept and Examples from the Vertebrate Embryo 1 -- Elizabeth D. Hay -- Formation of the Mesenchymal Cell in the Embryo 2 -- Definition of the Mesenchymal Cell 4 -- Examples of EMT in Higher Vertebrate Embryos 4 -- 2. Epithelium-Mesenchyme Transitions Are Crucial Morphogenetic -- Events Occurring During Early Development 12 -- Olivier Morali, Pierre Savagner and Lionel Larue -- Supracellular Architecture: The Dichotomy Between Epithelium -- and Mesenchyme 14 -- Embryonic Morphogenesis: A Harmonious Series of Transitions -- from One Cellular Architectural Type to Another 15 -- 3. The Neural Crest: A Model Developmental EMT 29 -- Donald F. Newgreen and Sonja J. McKeown -- The NC Is a Valuable Model for EMT 29 -- Defining the NC 29 -- The EMT of the NC Is Stereotyped 29 -- The Induction, EMT and Migration of NC Are Linked 32 -- The NC Is Induced by Cell Interactions 32 -- Genes and Molecules in the NC during Induction, EMT -- and Migration 33 -- Specific Transcription Factors Are Expressed by Nascent NC Cells 33 -- Motor Molecules and Genes in the NC That Contribute to EMT 34 -- 4. Epithelial-Mesenchymal Transformation in the Embryonic Heart 40 -- Raymond B. Runyan, Ronald L. Heimark, Todd D. Camenisch -- and Scott E. Klewer -- Description of EMT in Vivo 41 -- Development of Collagen Gel Culture 43 -- Identification of Components of the EMT Process 43 -- TGFb As a Mediator of EMT 45 -- TGFb Receptors 46 -- TGFb Activation 46 -- Extracellular Matrix in EMT 47 -- Other Growth Factors in EMT 48 -- Signal Transduction during EMT 48 -- Cell-Cell Regulation of EMT 49 -- Transcriptional Regulation of EMT 49 -- Clinical Significance of EMT in the Heart 50 -- Questions and Future Directions 50 -- 5. Epithelial-Extracellular Matrix (Cell-ECM) Interactions in Hydra 56 -- Michael P. Sarras, Jr. -- General Introduction to Hydra Structure and Tissue Dynamics 56 -- Composition and Supramolecular Organization of Hydra -- Extracellular Matrix 57 -- Biogenesis of Hydra ECM During Regeneration, Epithelial Repair -- Along the Longitudinal Axis, and During Normal Cell Turnover -- in the Adult Polyp 62 -- Epithelial Morphogenesis in Hydra Is Dependent on ECM -- Biogenesis as Monitored During Head Regeneration -- and Epithelial Repair Following Surgical Incision of the Bilayer 66 -- Role of Metalloproteinases in the Regulation of Cell-ECM -- Interactions in Hydra 68 -- 6. Regulation of the Epithelial-to-Mesenchymal Transition -- in Sea Urchin Embryos 77 -- Gary M. Wessel and Hideki Katow -- Sea Urchin Development: Summary 77 -- The Extracellular Matrix Involved in the EMT 80 -- Morphogenesis of the EMT 83 -- Molecular Mechanisms Involved in EMT 90 -- Signal Transduction in PMC Cell Surface Modifications 93 -- Gene Regulation in Cells that Undergo EMT 94 -- Future Implications 96 -- 7. Change of Epithelial Fate: Lessons from Gastrulation -- in Drosophila 101 -- Atish Ganguly and Y. Tony Ip -- Gastrulation in the Fly Embryo 101 -- Cellular Changes in the Presumptive Mesoderm 103 -- Dorsal-Ventral Patterning of the Blastoderm 103 -- Multifaceted Control of Gastrulation by Snail 104 -- 8. Cutaneous Wound Reepithelialization: -- A Partial and Reversible EMT 111 -- ValÄrie Arnoux, Christophe CÖme, Donna F. Kusewitt, -- Laurie G. Hudson and Pierre Savagner -- Cutaneous Wound Healing, a Multistep Process 112 -- Keratinocyte Activation, a Partial EMT 113 -- Migration of a Semi-Cohesive Sheet of Cells 116 -- Contribution of the Inflammatory Response to Reepithelialization 120 -- Transcriptional Control of Keratinocyte Migration 123 -- 9. Epithelial-Mesenchymal Transitions in Human Cancer 135 -- Veerle L. Van Marck and Marc E. Bracke -- The Molecular Basis of EMT 136 -- Features of EMT in Pathology 137 -- Morphological Markers of Cell Differentiation 140 -- Examples of EMT 142 -- Epithelium-Stroma Interactions 148 -- 10. Structural and Functional Regulation of Desmosomes 160 -- Spiro Getsios, Lisa M. Godsel and Kathleen J. Green -- Molecular Components of the Desmosome 160 -- Functional Regulation of Desmosome Assembly 168 -- 11. Epithelial Cell Plasticity by Dynamic Transcriptional Regulation -- of E-Cadherin 178 -- Geert Berx and Frans Van Roy -- E-Cadherin Transcriptional Regulation 179 -- Transcriptional Up-Regulation of E-Cadherin 180 -- Transcriptional Down-Regulation of E-Cadherin 181 -- E-Cadherin Transrepression in Human Tumors 185 -- E-Cadherin Gene Silencing by CpG Hypermethylation 185 -- 12. The Regulation of Catenins in Cancer 191 -- Maralice Conacci-Sorrell and Avri Ben-Ze'ev -- Gene Deletion or Inactivation of Catenins and E-Cadherin -- in Cancer Cells 191 -- The Wnt Signaling Pathway 193 -- Transcriptional Targets of b-Catenin in Cancer 194 -- Antiproliferative Responses to Oncogenic b-Catenin -- That Involve p53 and PML 194 -- Signaling by Plakoglobin 196 -- The Reciprocal Relationship between Cadherin-Mediated -- Adhesion and b-Catenin Signaling 197 -- Regulation of Cell-Cell Adhesion by Growth Factor Receptor -- Driven Phosphorylation 197 -- 13. Hepatocyte Growth Factor Regulates Transitions Between -- Epithelial and Mesenchymal Cellular Phenotypes During -- Normal Development and in Disease 203 -- Regina M. Day, Angelina Felici and Donald P. Bottaro -- Developmental Transitions between Epithelial and Mesenchymal Phenotypes 204 -- The Role of HGF Signaling in Tumor-Associated EMT 206 -- Occurrence of EMT in Tissue Fibrosis and Its Inhibition by HGF 209 -- 14. The Role of Insulin-Like Growth Factors in the Epithelial -- to Mesenchymal Transition 215 -- Sylvia Julien-Grille, Robert Moore, Laurence Denat, Olivier G. Morali, VÄronique Delmas, Alfonso Bellacosa -- and Lionel Larue -- IGFs and Regulation of Cell-Cell Adhesion: -- Cellular and Molecular Aspects 218 -- Signalling Pathways Activated by IGF-1R 220 -- Pathways Activated by IGF and Implicated in the Induction -- of the EMT 226 -- 15. TGFb-Dependent Epithelial-Mesenchymal-Transition 236 -- Marie-Luce Vignais and Patrick Fafet -- TGFb Signaling 237 -- Role of TGFb in Tumorigenesis and EMT 238 -- Role of the Three TGFb Isoforms and of Their Receptors -- in the EMT Process 239 -- Mechanisms and Signaling Pathways Involved in TGFb-Dependent EMTs 240 -- Role of the Smads 240 -- Role of Smad-Independent Signaling Pathways 240 -- Cross-Talk between Signaling Pathways 241 -- Conclusion and Perspectives 242 -- 16. The Ras and Src Signaling Cascades Involved in Epithelial -- Cell Scattering 245 -- Brigitte Boyer -- The Signaling Pathways Leading to EMT 245 -- Src Involvement in EMT 247 -- 17. Regulation of E-Cadherin-Mediated Cell-Cell Adhesion -- by Rho Family GTPases 255 -- Masato Nakagawa, Nanae Izumi and Kozo Kaibuchi -- Cadherin-Mediated Cell-Cell Adhesions 255 -- Rho GTPases Regulate Cadherin-Mediated Cell-Cell Adhesion 259 -- Cadherin-Mediated Cell-Cell Adhesion Affects -- Rho GTPase Activity 261 -- 18. Wnt Signaling Networks and Embryonic Patterning 267 -- Michael W. Klymkowsky -- Wnts and Their Receptors 268 -- Downstream of Frizzled, a Networking Nightmare 269 -- Analyzing Interactions 270 -- The Canonical Pathway 270 -- Dishevelled 273 -- Catenin Degradation 273 -- b-Catenin and Transcription Factor Interactions 274 -- Catenins and LEF/TCFs 274 -- Xenopus b-Catenin and LEF/TCFs 276 -- SOXs As Modulators of the Catenin Wnt Pathway 278 -- SOX-Catenin Interactions 279 -- SOX Modulation of Catenin-Signaling 279 -- 19. Cadherin-Mediated Cell-Cell Adhesion -- and the Microtubule Network 288 -- CÄcile Gauthier-RouviÅre, Marie Causeret, Franck Comunale -- and Sophie Charrasse -- Delivery of Cadherin and Catenin to the Cell Periphery -- through Microtubules 291 -- Cadherin-Dependent Cell-Cell Contact Regulates Microtubules -- Stability 292 -- Catenin-Dependent Regulation of Spindle Localization 292 -- 20. Matrix Metalloproteases and Epithelial-to-Mesenchymal -- Transition: Implications for Carcinoma Metastasis 297 -- Christine Gilles, Donald F |
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Newgreen, Hiroshi Sato -- and Erik W. Thompson -- General Considerations of the EMT 297 -- Matrix Metalloproteases 298 -- MMPs in Carcinoma Model Systems for the EMT 300 -- MMPs in Developmental EMT Systems 306 -- Regulation of MMPs by EMT-Associated Transcription Factors 309 -- Index 317 |
| Summary |
Epithelial phenotype is a dynamic stage of differentiation. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). This book introduces the concept of EMT. Part one describes main examples and models and part two reviews specific EMT molecular pathways |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Vertebrates -- Embryology
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Epithelium.
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Mesenchyme.
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Phenotype.
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Mesoderm -- physiology
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Epithelium
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Mesoderm
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Cell Differentiation -- physiology
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Epithelial Cells -- physiology
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Phenotype
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SCIENCE -- Life Sciences -- Developmental Biology.
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Epithelium.
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Mesenchyme.
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Mesoderm -- physiology.
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Cell Differentiation -- physiology.
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Epithelial Cells -- physiology.
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Phenotype.
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Vertebrates -- Embryology.
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Biomédecine.
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Sciences de la vie.
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Phenotype
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Epithelium
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Mesenchyme
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Vertebrates -- Embryology
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Epitheel-mesenchym-transformatie.
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| Form |
Electronic book
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| Author |
Savagner, Pierre
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| ISBN |
9780387286716 |
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0387286713 |
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1423724089 |
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9781423724087 |
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0306482398 |
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9780306482397 |
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6610945039 |
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9786610945030 |
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